SU 4312 CAS: 5812-07-7
MF: C17H16N2O
MW: 264.3
A potent and selective VEGFR (Flk/Flt) inhibitor.

SU 4312 (CAS 5812-07-7)

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Ansökan SU 4312 is a potent and selective VEGFR (Flk/Flt) inhibitor
Momsregistreringsnummer :: 5812-07-7
Purity: 98%
Molecular Weight: 264.3
Molecular Formula: C17H16N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SU 4312 is a selective and potent vascular endothelial cell growth factor receptor (VEGFR) inhibitor. Inhibition of Flk-1 (VEGFR-2) in neonatal rodent models of stroke, has been shown to limit endothelial cell proliferation and promote cell death. SU 4312 is an inhibitor of Flg, Flt-1 and PDGFR-β.


Konferenser

1. Schultheiss, C., et al. 2006. Angiogenesis. 9: 59-65. PMID: 16821113
2. Shimotake, J., et al. 2010. Stroke. 4: 343-349. PMID: 20101028

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml). Insoluble in water.
LAGRING :
Store at -20° C
Melting Point :
189.72° C (Predicted)
Boiling Point :
~497.1° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.68
IC50 :
tyrosine kinase activities of the PDGF β-receptor: IC50 = 4 µM (PAC-1 cells); tyrosine phosphorylation of p90: IC50 = 5 µM; VEGFR tyrosine kinase: IC50 = 0.8 µM; PDGFR tyrosine kinase: IC50 = 19.4 µM
pK Values :
pKa: 13.15, pKb: 4.21
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6450842
MDL Number :
MFCD00118147
SMILES :
CN(C)C1=CC=C(C=C1)C=C2C3=CC=CC=C3NC2=O

Download SDS (MSDS)

Certificate of Analysis

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SU 4312 (CAS 5812-07-7)  Produkt Citat

See how others have used SU 4312 (CAS 5812-07-7). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24416421  Gorman, JL. et al. 2014. PloS one. 9: e85537.

PMID: # 20844577  Eierhoff, T. et al. 2010. PLoS Pathog. 6: e1001099.

Citations 1 to 2 of 2 total
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