SU 16f CAS: 251356-45-3
MF: C24H22N2O3
MW: 386.44
A potent PDGFRβ inhibitor.

SU 16f (CAS 251356-45-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 120ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Ansökan SU 16f is a potent PDGFRβ inhibitor
Momsregistreringsnummer :: 251356-45-3
Purity: >98%
Molecular Weight: 386.44
Molecular Formula: C24H22N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SU 16f is a selective PDGFRβ inhibitor with an IC50=10nM. In vitro studies demonstrate that SU 16f also inhibits HUVEC and NIH3T3 cell proliferation with an IC50=0.11μM. In addition, SU 16f displays 14 fold selectivity towards PDGFRβ compared to Flk-1 (VEGFR2), 229-fold over Flg (FGFR1) and 10000-fold over EGFR. SU 16f is an inhibitor of Flk-1.


Konferenser

1. Sun, L., et al. 1999. J. Med. Chem. 42: 5120-5130. PMID: 10602697

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM). Insoluble in ethanol.
LAGRING :
Store at room temperature
Melting Point :
~285.24° C (Predicted)
Boiling Point :
~655.50° C (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D ~1.68 (Predicted)
IC50 :
PDGFRβ: IC50 = 10 nM; PDGFβ-stimulated proliferation: IC50 = 0.11 µM (EGFR-expressing NIH 3T3 cultures); Flk-1: IC50 = 0.14 µM; FGFR1: IC50 = 2.29 µM; EGF-stimulated proliferation: IC50 = 21.9 µM (EGFR-expressing NIH 3T3 cultures)
pK Values :
pKa: 4.62 (Predicted), pKb: 2.36 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
53396310
MDL Number :
MFCD03452699
SMILES :
CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=C(C=C(C=C3)C4=CC=CC=C4)NC2=O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 105ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.