SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM). SSR 69071 displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively).
1. Bidouard, J.P., et al. 2003. Eur. J. Pharmacol. 461: 49-52. 2. Varga, M., et al. 2003. Eur. J. Med. Chem. 38: 421-425 3. Kapui, Z., et al. 2003. J. Pharmacol. Exp.Ther. 305: 451-459.
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