SSR 69071 CAS: 344930-95-6
MF: C27H32N4O7S
MW: 556.63
A potent leukocyte elastase inhibitor.

SSR 69071 (CAS 344930-95-6)

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Alternativa namn: 2-[[6-Methoxy-4-(1-methylethyl)-1,1 -dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one
Ansökan SSR 69071 is a potent leukocyte elastase inhibitor
CAS Nr: 344930-95-6
Renhet: >98%
Molekylvikt: 556.63
Molekylär formel: C27H32N4O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM). SSR 69071 displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively).


Konferenser

1. Bidouard, J.P., et al. 2003. Eur. J. Pharmacol. 461: 49-52.
2. Varga, M., et al. 2003. Eur. J. Med. Chem. 38: 421-425
3. Kapui, Z., et al. 2003. J. Pharmacol. Exp.Ther. 305: 451-459.

Physical State :
Solid
Solubility :
Soluble in ethanol (40 mM), and DMSO (25 mM).
LAGRING :
Store at 4° C
Boiling Point :
763.26° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Neutrophil Elastase: IC50 = 3.9 nM (human)
Ki Data :
Elastase: Ki= 17 pM (human)Elastase: Ki= 1.7 nM (mouse); Elastase: Ki= 3.01 nM (rat); Elastase: Ki= 58 nM (rabbit); Elastase: Ki>100 nM (porcine);
pK Values :
pKb: 8.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD09027353
SMILES :
CC(C)C1=CC(=CC2=C1C(=O)N(S2(=O)=O)COC3=CC(=O)N4C=CC=C(C4=N3)OCCN5CCCCC5)OC

Download SDS (MSDS)

Certificate of Analysis

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SSR 69071 (CAS 344930-95-6)  Produkt Citat

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PMID: # 28837503  Pain. 2243-2258.

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