Sorafenib Tosylate CAS: 475207-59-1
MF: C21H16ClF3N4O3•C7H8SO3
MW: 637.03

Sorafenib Tosylate (CAS 475207-59-1)

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Alternativa namn: Sorafenib Tosylate is also known as BAY 43-9006 Tosylate.
Ansökan Sorafenib Tosylate is an inhibitor of Flk-1 (VEGFR), PDGFR and Raf kinases used for the treatment of human hepatocellular carcinoma.
Momsregistreringsnummer :: 475207-59-1
Purity: ≥99%
Molecular Weight: 637.03
Molecular Formula: C21H16ClF3N4O3•C7H8SO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Sorafenib Tosylate exerts broad-spectrum anticancer efficacy in vitro and in vivo via targeting b-Raf, c-Raf (Raf-1), as well as several receptor tyrosine kinases involved in neovascularization and tumor progression. These tyrosibne kinases targeted by Sorafenib Tosylate include vascular endothelial growth factor receptors 2/3 (VEGFR-2/Flk-1/KDR, VEGFR-3), platelet-derived growth factor receptor-beta (PDGFR-β), Flt-3, c-KIT, FGFR-1 (Flt-2) and RET. Sorafenib Tosylate is a drug used for the treatment of human hepatocellular carcinoma. In clinical use, the effect on HCC by Sorafenib Tosylate is limited. Sorafenib Tosylate is also known as BAY 43-9006, 4-methylbenzenesulfonate, and 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), DMSO (127 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
LAGRING :
Store at -20° C
Melting Point :
240-243° C
IC50 :
Melanocortin receptor 4: IC50 = 4.48 µM (human); Raf-1: IC50 = 6 nM; B-Raf: IC50 = 22 nM; VEGFR2: IC50 = 90 nM; mVEGFR2 (flk-1): IC50 = 15 nM; mVEGR-3: IC50 = 20 nM
pK Values :
pKa: 12.89 (Predicted), pKb: 2.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
49849879
MDL Number :
MFCD08235032
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)[O-].CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Download SDS (MSDS)

Certificate of Analysis

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Sorafenib Tosylate (CAS 475207-59-1)  Produkt Citat

See how others have used Sorafenib Tosylate (CAS 475207-59-1). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27029796  Thomas, VA. et al. 2016. AAPS J. 18: 923-32.

PMID: # 26070816  Lee, WR. et al. 2015. J Transl Med. 13: 191.

PMID: # 25035930  Nam, KW. et al. 2014. Biochem. Biophys. Res. Commun. 450: 1518-24.

PMID: # 32713860  J. Biosci.

PMID: # 29983874  Oncotarget. 28474-28485.

Citations 1 to 5 of 5 total
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