SN-6 is a selective Na+/Ca2+exchange (NCX) inhibitor, displaying some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. SN-6 has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943. This compound acts as an anti-ischemic, potently protecting against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).
1. Inoue, Y., Ito, K., Sakaue, T., Iwamoto, T. and Kita, S. 2004. Characterization of SN-6, a novel exchange inhibitor and its renal protective effect]. Clin Calcium. 14(8): 84-91. PMID: 15577102
2. Iwamoto, T. 2004. Forefront of Na+/Ca2+ exchanger studies: molecular pharmacology of Na+/Ca2+ exchange inhibitors. J. Pharmacol. Sci. 96(1): 27-32. PMID: 15359084
3. Iwamoto, T., Inoue, Y., Ito, K., Sakaue, T., Kita, S. and Katsuragi, T. 2004. The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol. Pharmacol. 66(1): 45-55. PMID: 15213295
4. Iwamoto, T. and Kita, S. 2006. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol. Pharmacol. 70(6): 2075-2083. PMID: 16973719
See how others have used SN-6 (CAS 415697-08-4). Click on the entry to view the PubMed entry .
PMID: # 30892074 Amarelle, L. et al. 2019. Am. J. Physiol. Lung Cell Mol. Physiol. 316: L1094-L1106.
PMID: # 26418956 van der Hagen, EA.|van Loon, EP.|Verkaart, S.|Latta, F.|Bindels, RJ.|Hoenderop, JG.| et al. 2015. Nephron. 131: 145-52.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.