Anti-Slfn11 Antibody (E-4) is a mouse monoclonal IgG1 κ Slfn11 antibody, cited in 17 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 733-765 near the C-terminus of Slfn11 of human origin
Slfn11 Antibody (E-4) is recommended for detection of Slfn11 of human origin by WB, IP, IF, IHC(P) and ELISA
Anti-Slfn11 Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Slfn11 (E-4): sc-374339.
At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Slfn11 Antibody (E-4). This work is in progress.
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Slfn11 Antibody (E-4) is a high quality monoclonal Slfn11 antibody (also designated SLFN8/9 antibody) suitable for the detection of the Slfn11 protein of human origin. Slfn11 Antibody (E-4) is available as both the non-conjugated anti-Slfn11 antibody form, as well as multiple conjugated forms of anti-Slfn11 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Schlafen family members are preferentially expressed in lymphoid tissues and are differentially regulated during thymocyte maturation. Schlafen proteins function as suppressors of cell growth and are thought to play a role in the maintenance of T cell quiescence. All members of the Schlafen family contain a conserved core domain and are substantially diversified at the N terminus. The prototype member of the Schlafen family, Slfn1, is transcriptionally unregulated during thymocyte positive selection and its induction leads to G0/G1 arrest, suggesting that Slfn1 participates in the regulation of cell cycle and potentially acts as a determining factor for apoptosis. Slfn1 and Slfn2 are both unregulated during the double-positive (DP) and single-positive (SP) stages of thymocyte development, whereas Slfn4 is down regulated at these stages. Changes in Schalfen protein expression may contribute to phenotypic differences seen in thymic subsets. Slfn11 (Schlafen family member 11), also known as SLFN8/9, is a 901 amino acid protein belonging to the Schlafen family.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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