SB 612111 hydrochloride CAS: 371980-98-2 (free base)
MF: C24H29Cl2NO•HCl
MW: 454.86
A piperidine derivative shown to act as a selective NOP (KOR-3) receptor antagonist.

SB 612111 hydrochloride (CAS 371980-98-2 (free base))

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Alternativa namn: (5S,7S)-7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride
Ansökan SB 612111 hydrochloride is a piperidine derivative shown to act as a selective NOP (KOR-3) receptor antagonist
CAS Nr: 371980-98-2 (free base)
Molekylvikt: 454.86
Molekylär formel: C24H29Cl2NO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SB 612111 hydrochloride is a piperidine derivative shown to act as a selective KOR-3 (NOP) receptor antagonist with Ki values of 0.33, 57.6, 160.5 and 2109 nM for KOR-3, μ-, κ- and δ-receptors respectively. SB 612111 hydrochloride has been shown to antagonize the pronociceptive action of nociceptin in an acute pain model and to potentiate the action of morphine in morphine-tolerant animal models.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and methanol (100 mM).
LAGRING :
Store at -20° C
Optical Activity :
α20/D -28.1°, c = 0.57 in IPA
Ki Data :
NOP: Ki= 0.33 nM; µ-receptors: Ki= 57.6 nM; κ-receptors: Ki= 160.5 nM; δ-receptors: Ki= 2109 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DE8381300
PubChem CID :
MDL Number :
MFCD12546333
SMILES :
CC1=CC=CC2=C1CC[[email protected]@H](C[[email protected]@H]2O)CN3CCC(CC3)C4=C(C=CC=C4Cl)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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