RO 19-4603 CAS: 99632-94-7
MF: C15H17N3O3S
MW: 319.38
An agent that binds with high affinity to GABAA receptors.

RO 19-4603 (CAS 99632-94-7)

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Ansökan RO 19-4603 is an agent that binds with high affinity to GABAA receptors
CAS Nr: 99632-94-7
Molekylvikt: 319.38
Molekylär formel: C15H17N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

RO 19-4603 is a benzodiazepine inverse agonist. Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively).


Konferenser

1. Wong, G. and Skolnick, P. 1992. Eur. J. Pharmacol. 225: 63-68.
2. June, H.L., et al. 1995. J. Pharmacol. Exp. Ther. 274: 1105-1112.
3. June, H.L., et al. 1998. Brain Res. 784: 256-275.

Solubility :
Soluble to 100 mM in DMSO
LAGRING :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC(C)(C)OC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CS3)C

Download SDS (MSDS)

Certificate of Analysis

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