RO 19-4603 is a benzodiazepine inverse agonist. Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABAA receptors (Ki values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively).
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