Retinoic Acid, all trans is the oxidized carboxylic acid form of retinol, known in the dietary context as Vitamin A. Retinal (sc-210778) is the aldehyde form of retinol required by the retina of the eye for light absorption and visual processing. Retinoic acid and the other retinoids are involved in a broad range of biological regulations, mediating differentiation, proliferation, and apoptosis. Binding of Retinoic Acid to the nuclear receptors RAR (retinoic acid receptor) and the RXR (retinoid X receptor) initiate signals for transcription and development. The intimate relationship between retinoids and cell cycle regulation has been implicated in suppression of oncogenic proliferation. Also available in a photoactivatable, caged form (sc-202089).
1. Leid, M., et al., 1992. Multiplicity generates diversity in the retinoic acid signalling pathways. Trends in biochemical sciences. 17(10): 427-33. PMID: 1333659
2. Allenby, G., et al., 1994. Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma. Retinoic acid receptor gamma binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid. The Journal of biological chemistry. 269(24): 16689-95. PMID: 8206989
3. Napoli, J L., et al., 1996. Biochemical pathways of retinoid transport, metabolism, and signal transduction. Clinical immunology and immunopathology. 80(3 Pt 2): S52-62. PMID: 8811064
4. Bushue, Nathan., et al., 2010. Retinoid pathway and cancer therapeutics. Advanced drug delivery reviews. 62(13): 1285-98. PMID: 20654663
See how others have used Retinoic Acid, all trans. Click on the entry to view the PubMed entry .
PMID: # 29072505 Pastorková, B. et al. 2017. Drug Chem Toxicol. 41: 1-7.
PMID: # 26345577 Briceño, A. et al. 2016. Neurotox Res. 29: 381-93.
PMID: # 26898150 Venne, P. et al. 2016. J Chromatogr A. 1438: 57-64.
PMID: # 26208032 Illés, P. et al. 2015. J. Agric. Food Chem. 63: 7074-83.
PMID: # 20547768 Apostolatos, H. et al. 2010. J Biol Chem. -.
PMID: # 20096012 Britschgi, A. et al. 2010. Br. J. Haematol. 149: 55-64.
PMID: # 18511453 Wang, C. et al. 2008. J. Biochem. 144: 313-321.
PMID: # 18280257 Kiningham, KK. et al. 2008. Free Radic. Biol. Med. 44: 1610-1616.
PMID: # 17596541 Soriano, AO. et al. 2007. Blood. 110: 2302-2308.
PMID: # 17283134 Ohnuma-Ishikawa, K. et al. 2007. Cancer Res. 67: 1019-1029.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.