Reticulol CAS: 26246-41-3
MF: C11H10O5
MW: 222.2
An isocoumarin metabolite shown to inactivate topoisomerase I.

Reticulol (CAS 26246-41-3)

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Ansökan Reticulol is an isocoumarin metabolite shown to inactivate topoisomerase I
CAS Nr: 26246-41-3
Renhet: >95%
Molekylvikt: 222.2
Molekylär formel: C11H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Reticulol acts as an isocoumarin metabolite that is produced by certain species of Streptomyces. It was first described as a potent inhibitor of cyclic nucleotide PDE (phosphodiesterase). Recent research shows Reticulol exhibits a Topo I (topoisomerase I) inactivation mechanism. It has been reported to cause inhibition of lung metastasis in the B16F10 melanoma model in a dose dependent manner.


Konferenser

1. Mitscher, L.A., et al. 1964. Experientia. 20: 258-259. PMID: 5856305
2. Furutani, Y., et al. 1975. J. Antibiot. 28: 558-560. PMID: 168174
3. Lim, D.S., et al. 2003. Chemotherapy. 49: 146-153. PMID: 12815208
4. Lim, D.S., et al. 2003. Chemotherapy. 49: 257-263. PMID: 14504438

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in water, methanol, DMSO, ethanol (moderate), and DMF.
LAGRING :
Store at -20° C
Melting Point :
160.69° C (Predicted)
Boiling Point :
473.24° C at 760 mmHg (Predicted)
Density :
1.43 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD11111617
SMILES :
CC1=CC2=CC(=C(C(=C2C(=O)O1)O)OC)O

Download SDS (MSDS)

Certificate of Analysis

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