Ras GAP Antibody (D-6) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
raised against amino acids 171-448 of Ras GAP of human origin
recommended for detection of Ras GAP p120 of mouse, rat and human origin by WB, IP, IF and ELISA
See Ras GAP (B4F8): sc-63 for Ras GAP antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Ras GAP Antibody (D-6) for WB applications. These reagents are now offered in bundles with Ras GAP Antibody (D-6) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins. p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state. Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific mutations. Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold. The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity, and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.