Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Q-VD-OPH protects neurotoxin-insulted neurons from apoptotic death, as well as displays minimal toxicity. In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of Q-VD-OPH is not o-methylated.
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See how others have used Q-VD-OPH (CAS 1135695-98-5). Click on the entry to view the PubMed entry .
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PMID: # 27123694 Strappazzon, F. et al. 2016. Autophagy. 12: 963-75.
PMID: # 26243583 Wang, H. et al. 2015. Nat Commun. 6: 7916.
PMID: # 24173220 Alymova, IV. et al. 2014. J. Virol. 88: 503-15.
PMID: # 32187520 Immunity. 52: 542-556.e13.
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