Q-VD-OPH CAS: 1135695-98-5
MF: C26H25F2N3O6
MW: 513.8

Q-VD-OPH (CAS 1135695-98-5)

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Alternativa namn: Q-VD-OPH is also known as Pan-Caspase Inhibitor (Fluoromethylketone).
Ansökan Q-VD-OPH is a low toxicity broad-spectrum inhibitor of caspase-3, caspase-1, caspase-8 and caspase-9.
CAS Nr: 1135695-98-5
Renhet: ≥95%
Molekylvikt: 513.8
Molekylär formel: C26H25F2N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). Q-VD-OPH protects neurotoxin-insulted neurons from apoptotic death, as well as displays minimal toxicity. In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of Q-VD-OPH is not o-methylated.


Konferenser

1. A. Rebbaa, et al.; Oncogene 22, 2805 (2003).
2. T.M. Caserta, et al.; Apoptosis 8, 345 (2003).
3. K. Patil & S.C. Sharma; Neuroreport 15, 981 (2004).

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM).
LAGRING :
Store at -20° C
Boiling Point :
808.87° C at 760 mmHg (Predicted)
Density :
1.35 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
caspase-3: IC50 <25 nM; caspase-1: IC50 = 50 nM; caspase-8: IC50 = 100 nM; caspase-9: IC50 = 430 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD08669741
SMILES :
CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2

Download SDS (MSDS)

Certificate of Analysis

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Q-VD-OPH (CAS 1135695-98-5)  Produkt Citat

See how others have used Q-VD-OPH (CAS 1135695-98-5). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 30261081  Suzuki, T.|Okamoto, T.|Katoh, H.|Sugiyama, Y.|Kusakabe, S.|Tokunaga, M.|Hirano, J.|Miyata, Y.|Fukuhara, T.|Ikawa, M.|Satoh, T.|Yoshio, S.|Suzuki, R.|Saijo, M.|Huang, DCS.|Kanto, T.|Akira, S.|Matsuura, Y.| et al. 2018. PLoS Pathog. 14: e1007299.

PMID: # 27123694  Strappazzon, F. et al. 2016. Autophagy. 12: 963-75.

PMID: # 26243583  Wang, H. et al. 2015. Nat Commun. 6: 7916.

PMID: # 24173220  Alymova, IV. et al. 2014. J. Virol. 88: 503-15.

PMID: # 32187520  Immunity. 52: 542-556.e13.

Citations 1 to 5 of 5 total
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