Pyrazolylpyrrole ERK Inhibitor CAS: 933786-58-4
MF: C22H17Cl2FN4O2
MW: 459.30
A potent inhibitor of ERK2.

Pyrazolylpyrrole ERK Inhibitor (CAS 933786-58-4)

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Ansökan Pyrazolylpyrrole ERK Inhibitor is a potent inhibitor of ERK2
CAS Nr: 933786-58-4
Renhet: >98%
Molekylvikt: 459.30
Molekylär formel: C22H17Cl2FN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Pyrazolylpyrrole ERK Inhibitor is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). Inhibits proliferation of Colo205 cells with an IC50 value of 0.54 µM.


Konferenser

1 Junttila, M.R., Li, S., Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 22 1-12 (2008). 2 Aronov, A.M., Baker, C., Bemis, G.W., et al. Flipped out: Structure-guided of select

Physical State :
Solid
Solubility :
Soluble in 1:1 ethanol:PBS (pH 7.2) (~0.5 mg/ml), ethanol (~ 5 mg/ml), DMSO (~ 1.5 mg/ml), and DMF (~ 2.5 mg/ml).
LAGRING :
Store at -20° C
IC50 :
Colo205 cells: IC50 = 0.54 µM
Ki Data :
ERK2: Ki= 2 nM; PKA: Ki= 0.39 µM; JNK3: Ki= 4 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1=CC(=CC(=C1)Cl)C2=CNNC2=C3C=C(N=C3)C(=O)NC(CO)C4=CC(=C(C=C4)F)Cl

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Certificate of Analysis

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Pyrazolylpyrrole ERK Inhibitor (CAS 933786-58-4)  Produkt Citat

See how others have used Pyrazolylpyrrole ERK Inhibitor (CAS 933786-58-4). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25695333  Samadani, R. et al. 2015. The Biochemical journal. 467: 425-38.

PMID: # 24509437  Dochi, T. et al. 2014. The Journal of general virology. 95: 1156-66.

Citations 1 to 2 of 2 total
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