Anti-PTP1B Antibody (D-4) is a mouse monoclonal IgG1 κ PTP1B antibody, cited in 12 publications, provided at 200 µg/ml
raised against amino acids 301-435 mapping at the C-terminus of PTP1B (protein tyrosine phosphatase) of human origin
PTP1B Antibody (D-4) is recommended for detection of PTP1B of human origin by WB, IP, IF, IHC(P) and ELISA
Anti-PTP1B Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PTP1B (D-4): sc-133259.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PTP1B Antibody (D-4) for WB and IHC(P) applications. These reagents are now offered in bundles with PTP1B Antibody (D-4) (see ordering information below).
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PTP1B Antibody (D-4) is a high quality monoclonal PTP1B antibody (also designated PTPN1 antibody) suitable for the detection of the PTP1B protein of human origin. PTP1B Antibody (D-4) is available as both the non-conjugated anti-PTP1B antibody form, as well as multiple conjugated forms of anti-PTP1B antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The phosphorylation of proteins at tyrosine residues has long been recognized as an important regulatory component of signal transduction. This is a reversible process, involving both enzymes that phosphorylate proteins on tyrosine residues as well as a rapidly expanding family of protein tyrosine phosphatases. These latter enzymes bear little resemblance to either the protein serine and protein threonine phosphatases or to the acid and alkaline phosphatases. In most tissues, the major PTPase is a vanadate- and molybdate-sensitive protein. On the basis of sequence analysis, PTP1B (PTPase 1B) expressed in human placenta exhibits similarities both with the common leukocyte antigen (CD45) and with LAR, a homolog of the neural adhesion molecule (NCAM). PTP1B is synthesized as a 435 amino acid precursor protein which is cleaved to generate the active 321 amino acid enzyme.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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