PTP Inhibitor V, PHPS1 CAS: 314291-83-3
MF: C21H15N5O6S
MW: 465.45
A cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2.

PTP Inhibitor V, PHPS1 (CAS 314291-83-3)

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Alternativa namn: PhenylHydrazonoPyrazolone Sulfonate 1
Ansökan PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2
CAS Nr: 314291-83-3
Renhet: ≥95%
Molekylvikt: 465.45
Molekylär formel: C21H15N5O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.


Konferenser

1. Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105:7275-7280. PMID: 18480264

Usage :
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
LAGRING :
Store at 4° C
IC50 :
Shp-2: IC50 = 2.1 µM; EC50PTP: IC50 = 5.4 µM; PTP1B: IC50 = 19 µM; Shp1: IC50 = 30 µM; mycobacterium MptpA: IC50 = 39 µM
Ki Data :
Shp-2: Ki= 0.73 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
[S](O)(=O)(=O)CC4=CC=C(NN=C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)C[N+]([O-])=O)C=C4

Download SDS (MSDS)

Certificate of Analysis

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PTP Inhibitor V, PHPS1 (CAS 314291-83-3)  Produkt Citat

See how others have used PTP Inhibitor V, PHPS1 (CAS 314291-83-3). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 30776010  Chen, CD. et al. 2019. J. Alzheimers Dis. 67: 1089-1106.

PMID: # 23189174  Tsang, YH. et al. 2012. PLoS ONE. 7: -.

PMID: # 22878065  Gupta, VK. et al. 2012. Biochim. Biophys. Acta. 1822: 1643-9.

PMID: # 31598397  Am J Cancer Res. 9: 1957-1969.

PMID: # 32054954  Sci Rep. 10: 2505.

PMID: # 27812544  JCI Insight. 1: e89020.

Citations 1 to 6 of 6 total
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