PTP Inhibitor V, PHPS1 (CAS 314291-83-3)

5.0(1)

Alternativa namn: PhenylHydrazonoPyrazolone Sulfonate 1

Ansökan PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2

CAS Nr: 314291-83-3

Renhet: ≥95%

Molekylvikt: 465.45

Molekylär formel: C₂₁H₁₅N₅O₆S

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC₅₀ and K_i = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC₅₀ = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.

Konferenser

1. Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105:7275-7280. PMID: 18480264

Usage :

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Physical State :

Solid

Solubility :

Soluble in DMSO (10 mg/ml).

LAGRING :

Store at 4° C

IC50 :

Shp-2: IC₅₀ = 2.1 µM; EC₅₀PTP: IC₅₀ = 5.4 µM; PTP1B: IC₅₀ = 19 µM; Shp1: IC₅₀ = 30 µM; mycobacterium MptpA: IC₅₀ = 39 µM

Ki Data :

Shp-2: K_i= 0.73 µM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

71433536

SMILES :

[S](O)(=O)(=O)CC4=CC=C(NN=C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)C[N+]([O-])=O)C=C4

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Certificate of Analysis

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PTP Inhibitor V, PHPS1 (CAS 314291-83-3) Produkt Citat

See how others have used PTP Inhibitor V, PHPS1 (CAS 314291-83-3). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 30776010 Chen, CD. et al. 2019. J. Alzheimers Dis. 67: 1089-1106.

PMID: # 23189174 Tsang, YH. et al. 2012. PLoS ONE. 7: -.

PMID: # 22878065 Gupta, VK. et al. 2012. Biochim. Biophys. Acta. 1822: 1643-9.

PMID: # 31598397 Am J Cancer Res. 9: 1957-1969.

PMID: # 32054954 Sci Rep. 10: 2505.

PMID: # 27812544 JCI Insight. 1: e89020.

Citations 1 to 6 of 6 total

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