PTP Inhibitor IV CAS: 329317-98-8
MF: C26H26F6N2O4S2
MW: 608.61
A potent, reversible, competitive, & active-site directed inhibitor of PTP.

PTP Inhibitor IV (CAS 329317-98-8)

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Alternativa namn: bis(4-Trifluoromethylsulfonamidophenyl)-1,4-diisopropylbenzene; Protein Tyrosine Phosphatase Inhibitor IV
Ansökan PTP Inhibitor IV is a potent, reversible, competitive, & active-site directed inhibitor of PTP
CAS Nr: 329317-98-8
Renhet: ≥95%
Molekylvikt: 608.61
Molekylär formel: C26H26F6N2O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PTP Inhibitor IV is an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic which acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases. PTP Inhibitor IV is an inhibitor of PTP β, PTP ε, PTP μ, PTP σ, PTP-MEG, PTP1B and SH-PTP2.


Konferenser

1. Huang, Ping., et al., 2003. Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. Bioorganic & medicinal chemistry. 11(8): 1835-49. PMID: 12659770
2. Shao, Weijian., et al., 2005. Bisphosphonates stimulate an endogenous nonselective cation channel in Xenopus oocytes: potential mechanism of action. American journal of physiology. Cell physiology. 289(2): C248-56. PMID: 15788487

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), and ACN.
LAGRING :
Store at 4° C
Boiling Point :
~578.0° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
SHP-2: IC50 = 1.8 µM; PTP1B: IC50 = 2.5 µM; PTP-ε: IC50 = 8.4 µM; PTP-Meg-2: IC50 = 13 µM; PTP-σ: IC50 = 20 µM; PTP-β: IC50 = 6.4 µM; PTP-: IC50 = 6.7 µM
pK Values :
pKa: 4.40 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD06660111
SMILES :
CC(C)(C1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)NS(=O)(=O)C(F)(F)F)C3=CC=C(C=C3)

Download SDS (MSDS)

Certificate of Analysis

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PTP Inhibitor IV (CAS 329317-98-8)  Produkt Citat

See how others have used PTP Inhibitor IV (CAS 329317-98-8). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 23314616  Kim, EJ. et al. 2013. Inflammation research : official journal of the European Histamine Research Society .. [et al.]. 62: 377-86.

PMID: # 22288587  Lee, SM. et al. 2012. Clinical and experimental immunology. 167: 438-46.

PMID: # 26175932  Am J Cancer Res. 5: 1610-20.

PMID: # 22043923  Immunology. 226-35.

Citations 1 to 4 of 4 total
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