PTP CD45 Inhibitor is a cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 μM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). PTP CD45 Inhibitor is not able to effectively inhibit PTPIB (IC50 <30 μM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent.
1. Urbanek, R.A., et al. 2001. J. Med. Chem. 44: 1777-1793. PMID: 11356112
See how others have used PTP CD45 Inhibitor (CAS 345630-40-2). Click on the entry to view the PubMed entry .
PMID: # 24231767 Novák, J. et al. 2014. Molecular immunology. 57: 302-9.
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