Anti-PTEN Antibody (A2B1) is a mouse monoclonal IgG1 κ PTEN antibody, cited in 455 publications, provided at 200 µg/ml
raised against amino acids 388-400 mapping at the C-terminus of PTEN of human origin
Anti-PTEN Antibody (A2B1) is recommended for detection of PTEN of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-PTEN Antibody (A2B1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PTEN (A2B1): sc-7974.
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) and m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) are the preferred secondary detection reagents for PTEN Antibody (A2B1) for WB and IHC(P) applications. These reagents are now offered in bundles with PTEN Antibody (A2B1) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PTEN Antibody (A2B1) is a high quality monoclonal PTEN antibody (also designated phosphatase and tensin homolog antibody) suitable for the detection of the PTEN protein of mouse, rat and human origin. PTEN Antibody (A2B1) is available as both the non-conjugated anti-PTEN antibody form, as well as multiple conjugated forms of anti-PTEN antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. Due to the involvment of the PTEN antigen in a broad range of cancers, the PTEN Antibody (A2B1) is an important research tool. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm and shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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