The PtdIns phosphates play an important role in the generation and transduction of intracellular signals. PtdIns-(4,5)-P2-biotinamide is an affinity probe which allows PIP2 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(4,5)-P2 to function as a general probe for any protein with a high affinity binding interaction with inositol-(4,5)-diphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
1 Rückle, T., Schwarz, M.K., Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'?. Nature Reviews Drug Discovery 5 903-918 (2006).
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