PSB 1115 CAS: 409344-71-4 anhydrous
MF: C14H13N4O5SK
MW: 388.44
An Adenosine A2B-R antagonist.

PSB 1115 (CAS 409344-71-4 anhydrous)

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Alternativa namn: 1-Propyl-8-(4-sulfophenyl)xanthine potassium salt hydrate
Ansökan PSB 1115 is an Adenosine A2B-R antagonist
CAS Nr: 409344-71-4 anhydrous
Renhet: ≥98%
Molekylvikt: 388.44
Molekylär formel: C14H13N4O5SK
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PSB 1115 is a highly selective, water-soluble, human Adenosine A2B-R antagonist. Ki values are 53.4 > 10000 and > 10000 nM at human Adenosine A2B-R, Adenosine A1-R and Adenosine A3-R, respectively. This compound is also selective versus rat Adenosine A1-R and Adenosine A2A-R (Ki values are 2200 and 24000 nM, respectively). PSB 1115 is an inhibitor of Adenosine A1-R.


Konferenser

1. Muller, C.E., et al. 1998. Bioorg. Med. Chem. 6: 707-719.
2. Hayallah, A.M., et al. 2002. J. Med. Chem. 45: 1500-1510.
3. Abo-Salem, O.M., et al. 2004. J. Pharmacol. Exp. Ther. 308: 358-366.
4. Yan, L. and Muller, C.E. 2004. J. Med. Chem. 47: 1031-1043.

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mM), and water (5 mM).
LAGRING :
Desiccate at 4° C
Refractive Index :
n20D ~1.64 (Predicted)
Ki Data :
Adenosine A2B-R: Ki= 53.4 nM (human); A1 receptor: Ki= 2.2 µM (rat); Adenosine A1-R: Ki= >10 µM (human); Adenosine A3-R: Ki= >10 µM (human); A2A receptor: Ki= 24 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD07784510
SMILES :
CCCN1C(=O)C2=C(NC1=O)N=C(N2)C3=CC=C(C=C3)S(=O)(=O)[O-].[K+].O.O.O

Download SDS (MSDS)

Certificate of Analysis

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PSB 1115 (CAS 409344-71-4 anhydrous)  Produkt Citat

See how others have used PSB 1115 (CAS 409344-71-4 anhydrous). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 28054654  Asano, T. et al. 2017. Sci Rep. 7: 40214.

PMID: # 24663055  He, J. et al. 2014. Respiration. 87: 394-407.

PMID: # 24966910  Yang, Y. et al. 2014. Int J Clin Exp Pathol. 7: 2006-18.

PMID: # 32103051  Sci Rep. 10: 3555.

PMID: # 32207522  Toxicol. Sci.

Citations 1 to 5 of 5 total
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