Proteasome Inhibitor I CAS: 158442-41-2
MF: C32H50N4O8
MW: 618.8
A selective inhibitor of chymotrypsin-like activities in the 26S proteasome (MCP).

Proteasome Inhibitor I (CAS 158442-41-2)

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Alternativa namn: Z-Ile-Glu(OtBu)-Ala-Leu-CHO
Ansökan Proteasome Inhibitor I is a selective inhibitor of chymotrypsin-like activities in the 26S proteasome (MCP)
CAS Nr: 158442-41-2
Molekylvikt: 618.8
Molekylär formel: C32H50N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Proteasome Inhibitor is a synthetic peptide (Z-Ile-Glu(OtBu)-Ala-Leu-CHO) which selectively inhibits chymotrypsin-like activities in the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Additionally, Proteasome Inhibitor acts as anti-neoplytic agent and induces apoptosis in different leukemia cell lines. Furthermore Proteasome Inhibitor is an inhibitor for the deubiquitinating Enzyme, and causes accumulation of ubiquitinylated proteins in neuronal cells. Proteasome Inhibitor prevents the activation of NF-κB in response to TNF-α or okadaic acid through inhibition of IκBα degradation.


Konferenser

1. Traenckner, E.B. et al. 1994. EMBO J. 13(22): 5433-5441. PMID: 7957109
2. Figueiredo-Pereira, M.E. et al. 1994. J. Neurochem. 63(4): 1578-1581. PMID: 7931314
3. Mori, S. et al. 1995. J. Biol. Chem. 270(49): 29447-29452. PMID: 7493983
4. Griscavage, J.M. et al. 1996. Proc. Natl. Acad. Sci. U.S.A. 93(8): 3308-3312. PMID: 8622934

Usage :
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Appearance :
Lyophilized
Physical State :
Solid
Sequence :
Z-Ile-Glu(OtBu)-Ala-Leu-CHO
LAGRING :
Desiccate at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC[[email protected]@H](C)[[email protected]@H](C(=O)N[[email protected]@H](CCC(=O)OC(C)(C)C)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CC(C)C)C=O)NC(=O)OCC1=CC=CC=C1

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Certificate of Analysis

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Proteasome Inhibitor I (CAS 158442-41-2)  Produkt Citat

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Citations 1 to 1 of 1 total

PMID: # 22020336  Fransson, S. et al. 2012. Oncogene. 31: 3277-86.

Citations 1 to 1 of 1 total
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