The major eicosanoid product of mast cells, certain macrophages, and the predominant PG in the cerebral spinal fluid. PGD2 inhibits platelet aggregation, induces sleep, causes flushing, vasodilation and nasal congestion, and immune modulation, acting through at least two 7-transmembrant G protein-coupled receptors, DP1 and DP2 (CRTH2). PGD2-biotinamide is an affinity probe which allows PGD2 to be detected through an interaction with the biotin ligand. It was designed to allow PGD2 to be detected in complexes with transmembrane receptors and/or nucleic acid or protein binding partners, thus it is a tool to be used in the general elucidation of the mechanism of action of PGs.
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