PKSI-527 CAS: 128837-71-8
MF: C25H31N3O4•HCl
MW: 473.99
A highly selective plasma kalikrein inhibitor that can be used for affinity purification of kalikrein.

PKSI-527 (CAS 128837-71-8)

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Alternativa namn: trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide
Ansökan PKSI-527 is a highly selective plasma kalikrein inhibitor that can be used for affinity purification of kalikrein
CAS Nr: 128837-71-8
Renhet: ≥95%
Molekylvikt: 473.99
Molekylär formel: C25H31N3O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PKSI-527 is a highly selective plasma kallikrein inhibitor (Ki = 0.81 μM) which can be used for affinity purification of kalikrein. It suppresses collagen-induced arthritis in a mouse model. Additionally, PKSI-527 has been shown to synergize with NO donors producing antithrombotic effects.


Konferenser

1: K. Wanaka et al. Chem. Pharm. Bull. 1992 40 1814 2: M. Tada et al. Biol. Pharm. Bull. 2001 24 520 3: Y. Fujimori et al. Agents Actions 1993 39 42 4: H. Ikarugi et al. Thromb. Res. 2005 116 403

Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml).
LAGRING :
Store at -20° C
Ki Data :
selective plasma kalikrein: Ki= 0.81 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1CC(CCC1CN)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)CC(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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PKSI-527 (CAS 128837-71-8)  Produkt Citat

See how others have used PKSI-527 (CAS 128837-71-8). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 29303013  Immunopharmacol Immunotoxicol. 40: 134-148.

PMID: # 32376801  JCI Insight. 5:

PMID: # 32050765  J. Agric. Food Chem.

Citations 1 to 3 of 3 total
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