PKSI-527 (CAS 128837-71-8)

5.0(1)

Alternativa namn: trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide

Ansökan PKSI-527 is a highly selective plasma kalikrein inhibitor that can be used for affinity purification of kalikrein

CAS Nr: 128837-71-8

Renhet: ≥95%

Molekylvikt: 473.99

Molekylär formel: C₂₅H₃₁N₃O₄•HCl

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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PKSI-527 is a highly selective plasma kallikrein inhibitor (K_i = 0.81 μM) which can be used for affinity purification of kalikrein. It suppresses collagen-induced arthritis in a mouse model. Additionally, PKSI-527 has been shown to synergize with NO donors producing antithrombotic effects.

Konferenser

1: K. Wanaka et al. Chem. Pharm. Bull. 1992 40 1814 2: M. Tada et al. Biol. Pharm. Bull. 2001 24 520 3: Y. Fujimori et al. Agents Actions 1993 39 42 4: H. Ikarugi et al. Thromb. Res. 2005 116 403

Physical State :

Solid

Solubility :

Soluble in water (5 mg/ml).

LAGRING :

Store at -20° C

Ki Data :

selective plasma kalikrein: K_i= 0.81 µM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

3035562

SMILES :

C1CC(CCC1CN)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)CC(=O)O.Cl

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Certificate of Analysis

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PKSI-527 (CAS 128837-71-8) Produkt Citat

See how others have used PKSI-527 (CAS 128837-71-8). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 29303013 Immunopharmacol Immunotoxicol. 40: 134-148.

PMID: # 32376801 JCI Insight. 5:

PMID: # 32050765 J. Agric. Food Chem.

Citations 1 to 3 of 3 total

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