Pitavastatin Lactone CAS: 141750-63-2
MF: C25H22FNO3
MW: 403.45
A major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase.

Pitavastatin Lactone (CAS 141750-63-2)

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Ansökan Pitavastatin Lactone is a major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase
Momsregistreringsnummer :: 141750-63-2
Purity: ≥95%
Molecular Weight: 403.45
Molecular Formula: C25H22FNO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Pitavastatin Lactone is a major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase. Studies have shown that conversion between the acid and lactone forms of pitavastatin occurs in the body and that these two forms differ in substrate activity tow.


Konferenser

1. Miners, J.O., et al. 2002. Toxicology 181: 453-456. PMID: 12505351
2. Prueksaritanont, T., et al. 2002. Drug Metab. Dispos. 30: 505-512. PMID: 11950779
3. Benet, L.Z., et al. 2003. Curr. Drug Metab. 4: 393-398. PMID: 14529371
4. Lin, J., et al. 2003. Clin. Pharmacokinet. 42: 59-98. PMID: 12489979
5. Fujino, H., et al. 2004. Xenobiotica. 34: 961-971. PMID: 15801541
6. Yamada, I., et al. 2003. Xenobiotica. 33: 789-803. PMID: 12893526
7. Tian, L., et al. 2008. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 865: 127-132. PMID: 18342583

Appearance :
Powder
Physical State :
Solid
LAGRING :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9801294
SMILES :
OC1C[[email protected]](OC(=O)C1)\\C=C\\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1

Download SDS (MSDS)

Certificate of Analysis

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Pitavastatin Lactone (CAS 141750-63-2)  Produkt Citat

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Citations 1 to 1 of 1 total

PMID: # 25318994  Hosaka, S. et al. 2015. Drug Metab. Dispos. 43: 27-33.

Citations 1 to 1 of 1 total
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