PIT is a purinergic P2Y receptor ligand. Displays mixed antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y1 receptor and sympathetic/purinergic nerve stimulation).
Spedding et al (1975) Antagonism of adenosine 5′-triphosphate-induced relaxation by 2-2′-pyridylisatogen in the taenia of guinea-pig caecum. Br.J.Pharmacol. 53 575. King et al (1996) Potentiation by 2,2′-pyridylisatogen tosylate of ATP-responses at a reco
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