PI-103 is a cell-permeable pyridinylfuranopyrimidine compound that acts as an ATP-competitive inhibitor of DNA-PK, PI 3-kinase (Class IA), and FRAP (mTOR) complex 1 and 2. Studies suggest that PI-103 can induce apoptosis and an arrest in the cell cycle by inhibition of the aforementioned proteins. When PI-103 is combined with rapamycin, a prototypic mTORC1 inhibitor, synergistic suppression of AKT and ribosomal S6 protein phosphorylation are observed. In addition, PI-103 has been seen to have nominal effects inhibiting basal Na+ transport, but is very effective in abolishing insulin-induced Na+ absorption in the nephron.
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See how others have used PI-103 (CAS 371935-74-9). Click on the entry to view the PubMed entry .
PMID: # 30731136 Höllerhage, M. et al. 2019. Neuropharmacology. 149: 13-26.
PMID: # 26355082 Kwon, YC. et al. 2015. J. Virol. 89: 11549-56.
PMID: # 17804702 Fan, QW. et al. 2007. Cancer Res. 67(17): 7960-7965.
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