PGP-4008 CAS: 365565-02-2
MF: C26H23N3O
MW: 393.5
A selective P-glycoprotein inhibitor.

PGP-4008 (CAS 365565-02-2)

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Ansökan PGP-4008 is a selective P-glycoprotein inhibitor
CAS Nr: 365565-02-2
Renhet: ≥98%
Molekylvikt: 393.5
Molekylär formel: C26H23N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PGP-4008 is a selective P-glycoprotein (Pgp)inhibitor. It effectively reverses Pgp mediated drug resistance in NCI/ADR cells, but has no effect on the drug sensitivities of MCF-7/VP cells that overexpress MRP1.


Konferenser

B.D. Lee, et al.; Oncol. Res. 14, 49 (2003). B.D. Lee, et al.; J. Med. Chem. 47, 1413 (2004).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol, 100%ethanol (3 mg/ml), and DMSO (20 mg/ml).
LAGRING :
Store at -20° C
Melting Point :
261.3° C (Predicted)
Boiling Point :
~678.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
pK Values :
pKa: 13.63 (Predicted), 7.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD03452998
SMILES :
C1CN(C2=NC3=CC=CC=C3C(=C21)NC(=O)CC4=CC=CC=C4)CC5=CC=CC=C5

Download SDS (MSDS)

Certificate of Analysis

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PGP-4008 (CAS 365565-02-2)  Produkt Citat

See how others have used PGP-4008 (CAS 365565-02-2). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30738829  EBioMedicine. 251-262.

Citations 1 to 1 of 1 total
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