Pertussis Toxin (islet-activating protein) CAS: 70323-44-3
A toxin that blocks reduction of adenylate cyclase activity.

Pertussis Toxin (islet-activating protein) (CAS 70323-44-3)

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Synonym: PTX;Holotoxin
Ansökan A toxin that blocks reduction of adenylate cyclase activity
Momsregistreringsnummer :: 70323-44-3
Purity: >99%
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pertussis Toxin (islet-activating protein), a toxin originally isolated from Bordetella pertussis, has been shown to catalyze ADP-ribosylation of a protein in membrane preparation from rat C6 glioma cells. In addition, exposure of Chinese hamster ovary cells in culture to this compound has resulted in a clustered growth pattern response. Other experiments have shown Pertussis Toxin to block the ability of inhibitory hormones to reduce adenylate cyclase activity and enhance the ability of stimulatory hormones to activate the enzyme. Mechanistic studies have shown this toxin to consist of subunit A (active) promoter, which disrupts transmembrane signaling by ADP-ribosylating eukaryotic G-proteins, and B (binding) oligomer which helps the toxin bind to cells in vivo.


1. Tamura, M., et al. 1982. Biochemistry. 21: 5516-5522. PMID: 6293544
2. Hewlett, E.L., et al. 1983. Infect. Immun. 40: 1198-1203. PMID: 6682833
3. Bokoch, G.M., et al. 1983. J. Biol. Chem. 258: 2072-2075. PMID: 6296122
4. Kaslow, H.R., et al. 1987. Biochemistry. 26: 123-127. PMID: 3030399
5. Kaslow, H.R. and Burns, D.L. 1992. FASEB J. 6: 2684-2690. PMID: 1612292

Physical State :
Derived From :
Bordetella pertussis
Solubility :
Soluble in water (Miscible).
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
MDL Number :

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Pertussis Toxin (islet-activating protein)  Produkt Citat

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PMID: # 3158374  Fujita, N. et al. 1985. Brain Res. 333: 231-236.

Citations 1 to 1 of 1 total
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