PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 is a cell-permeable, ATP-binding pocket-targeting, 5-bromoindolinone analog of SU6668. PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 is equally potent as SU6668 in inhibiting PDGFR, while increasing activity against VEGFR2 and FGFR1 in cell-free kinase assays. Inhibits cell proliferation mediated by VEGF, FGF, and PDGFβ. Little effect against EGF-mediated cell proliferation or EGFR in vitro kinase activity.
Sun, L. et al. 1999. J. Med. Chem. 42, 5120.
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