PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 MF: C18H17BrN2O3
MW: 389.2
A potent PDGFR, VEGFR2, and FGFR1 inhibitor.

PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668

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Alternativa namn: (Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid
Ansökan PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 is a potent PDGFR, VEGFR2, and FGFR1 inhibitor
Molecular Weight: 389.2
Molecular Formula: C18H17BrN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 is a cell-permeable, ATP-binding pocket-targeting, 5-bromoindolinone analog of SU6668. PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 is equally potent as SU6668 in inhibiting PDGFR, while increasing activity against VEGFR2 and FGFR1 in cell-free kinase assays. Inhibits cell proliferation mediated by VEGF, FGF, and PDGFβ. Little effect against EGF-mediated cell proliferation or EGFR in vitro kinase activity.


Konferenser

Sun, L. et al. 1999. J. Med. Chem. 42, 5120.

Physical State :
Solid
Solubility :
Soluble in DMSO
LAGRING :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
53735577
SMILES :
C1=C(C=CC2=C1C(C(N2)=O)=CC3=C(C(=C(C)[N]3)CCC(O)=O)C)Br

Download SDS (MSDS)

Certificate of Analysis

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