PDGFR Tyrosine Kinase Inhibitor VI, SU6668 CAS: 210644-62-5
MF: C18H18N2O3
MW: 310.4
A potent ATP-competitive inhibitor against tyrosine kinases.

PDGFR Tyrosine Kinase Inhibitor VI, SU6668 (CAS 210644-62-5)

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Ansökan PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a potent ATP-competitive inhibitor against tyrosine kinases
Momsregistreringsnummer :: 210644-62-5
Purity: >97%
Molecular Weight: 310.4
Molecular Formula: C18H18N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 µM, respectively).


Konferenser

Godl, K., et al. 2005. Cancer Res. 65, 6919. Laird, A.D., et al. 2002. FASEB J. 16, 681. Krystal, G.W., et al. 2001. Cancer Res. 61, 3660. Smolich, B.D., et al. 2001. Blood 97, 1413. Laird, A.D., et al. 2000. Cancer Res. 60, 4152. Shaheen, R.M., et al. 1999. Cancer Res. 59, 5412. Sun, L. et al. 1999. J. Med. Chem. 42, 5120.

Physical State :
Solid
Solubility :
Soluble in DMSO
LAGRING :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5329099
SMILES :
CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O

Download SDS (MSDS)

Certificate of Analysis

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PDGFR Tyrosine Kinase Inhibitor VI, SU6668 (CAS 210644-62-5)  Produkt Citat

See how others have used PDGFR Tyrosine Kinase Inhibitor VI, SU6668 (CAS 210644-62-5). Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 16849418  Kim, DW. et al. 2006. J. Clin. Endocrinol. Metab. 91: 4070-4076.

PMID: # 16061676  Godl, K. et al. 2005. Cancer Res. 65: 6919-6926.

PMID: # 16266995  Bagley, RG. et al. 2005. Cancer Res. 65(21): 9741-9750.

PMID: # 15701856  Davis, DW. et al. 2005. Clin. Cancer Res. 11: 678-689.

PMID: # 14967441  Lu, B. et al. 2004. Int. J. Radiat. Oncol. Biol. Phys. 58: 844-850.

PMID: # 11978732  Laird, AD. et al. 2002. FASEB J. 16(7): 681-690.

PMID: # 11222388  Smolich, BD. et al. 2001. Blood. 97: 1413-1421.

PMID: # 10945623  Laird, AD. et al. 2000. Cancer Res. 60: 4152-4160.

PMID: # 10804085  Ellis, LM. et al. 2000. Oncologist. 5 Suppl 1: 11-15.

Citations 1 to 9 of 9 total
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