PDGFR Tyrosine Kinase Inhibitor IV CAS: 627518-40-5
MF: C18H16FN3O2
MW: 325.3
An indenopyrazole agent that displays potent antiproliferative properties.

PDGFR Tyrosine Kinase Inhibitor IV (CAS 627518-40-5)

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Alternativa namn: 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine
Ansökan PDGFR Tyrosine Kinase Inhibitor IV is an indenopyrazole agent that displays potent antiproliferative properties
Momsregistreringsnummer :: 627518-40-5
Purity: >98%
Molecular Weight: 325.3
Molecular Formula: C18H16FN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PDGFR Tyrosine Kinase Inhibitor IV is a indenopyrazole compound that displays potent antiproliferative properties in human tumor cell lines. It acts as a reversible ATP-competitive inhibitor of PDGFR but exhibits less actibity towards Lck, c-Src, and Fyn while exhibiting little to no inhibition toward VEGFR, HER-2, Cdk′s-1,-2,-4 &-7, bFGFR-1 and EGFR. PDGFR Tyrosine Kinase Inhibitor IV is cell-permeable. PDGFR Tyrosine Kinase Inhibitor IV is an inhibitor of c-Abl, PDGFR-α and PDGFR-β.


Konferenser

1. Ho, C.Y., et al. 2005. J. Med. Chem. 48: 8163-8173. PMID: 16366598

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), water (<2 mg/ml), and methanol.
LAGRING :
Store at -20° C
Melting Point :
154° C
Boiling Point :
~528.77° C at 760 mmHg (Predicted)
Density :
~1.37 g/cm3 (Predicted)
Refractive Index :
n20D 1.67
IC50 :
tumor cell lines: IC50 = <33 nM (human); PDGFR-β: IC50 = 4.2 nM; c-Abl: IC50 = 22 nM; Lck: IC50 = 100 nM; c-Src: IC50 = 185 nM; Fyn: IC50 = 378 nM; VEGFR: IC50 = 3.1 µM; HER-2: IC50 = >10 µM; Cdk′s-1,-2,-4 &-7: IC50 = >10 µM; bFGFR-1: IC50 = 45.8 µM; EGFR: IC50 = >100 µM; PDGFR-α: IC50 = 45 nM; A-375 (Malignant melanoma cells): IC50 = 7 nM (human); NCI-H460 (Non-small cell lung carcinoma): IC50 = 10 nM (human); LoVo (Colon adenocarcinoma cells): IC50 = 17 nM (human)
pK Values :
pKa: 14.00, pKb: 3.10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9797370
SMILES :
COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC

Download SDS (MSDS)

Certificate of Analysis

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PDGFR Tyrosine Kinase Inhibitor IV (CAS 627518-40-5)  Produkt Citat

See how others have used PDGFR Tyrosine Kinase Inhibitor IV (CAS 627518-40-5). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 31881074  PLoS Pathog. 15: e1008221.

Citations 1 to 1 of 1 total
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