PDGFR Tyrosine Kinase Inhibitor III is a cell-permeable, potent, selective, and ATP-competitive inhibitor of the PDGFR family of tyrosine kinases (IC50 = 50 nM for PDGFR-α, 80 nM for PDGFR-β, 50 nM for c-Kit, and 230 nM for Flt-3/Flk-2). PDGFR Tyrosine Kinase Inhibitor III inhibits the activities of other kinases only at much higher concentrations (IC50 > 30μM for EGFR, FGFR, Src, PKA, and PKC). Reported to block PDGF-BB-induced proliferation of porcine aorta smooth muscle cells (IC50 = 250 nM).
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See how others have used PDGFR Tyrosine Kinase Inhibitor III (CAS 205254-94-0). Click on the entry to view the PubMed entry .
PMID: # 26461489 Friedman, AA. et al. 2015. PloS one. 10: e0140310.
PMID: # 24901498 Raz, O. et al. 2014. PloS one. 9: e95156.
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