PD 166866 (CAS 192705-79-6)

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Ansökan PD 166866 is an inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for bFGF

Momsregistreringsnummer :: 192705-79-6

Purity: 98%

Molecular Weight: 396.44

Molecular Formula: C₂₀H₂₄N₆O₃

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

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PD 166866 is a potent inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for FGF-2 (bFGF). It has no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases, or MEK, PKC, or CDK4. PD 166866 is an inhibitor of Flg (FGFR1).

Konferenser

Zhu, X., et al.: Science, 251, 90 (1991), Davies, D.E., et al.: Biochem. Pharmacol., 51, 1101 (1996), Panek, R.L., et al.: J. Pharmacol. Exp. Ther., 286, 569 (1998), Iacoangeli, A., et al.: Biochimie, 82, 35 (2000),

Physical State :

Solid

Solubility :

Soluble in DMSO (≥10 mg/ml).

LAGRING :

Store at -20° C

Melting Point :

291-293°C (lit.)

Density :

1.28 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.64 (Predicted)

IC50 :

Fibroblast growth factor receptor 1: IC₅₀ = 48 nM (human); c-Src : IC₅₀ = > 50 µM; Cyclin-dependent kinase 4: IC₅₀ = >40 µM (human); Fibroblast growth factor receptor 3: IC₅₀ = 60 nM (human); HUVEC₅₀ : IC₅₀ = 100 nM (human); Fibroblast growth factor receptor 2: IC₅₀ = 60 nM (human); C6 : IC₅₀ = >25 µM (rat)

pK Values :

pK_a: 10.15, pK_b: 2.95

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

1

PubChem CID :

5328127

MDL Number :

MFCD12922514

SMILES :

CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC

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Certificate of Analysis

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