PD 166866 CAS: 192705-79-6
MF: C20H24N6O3
MW: 396.44
An inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for bFGF.

PD 166866 (CAS 192705-79-6)

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Ansökan PD 166866 is an inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for bFGF
Momsregistreringsnummer :: 192705-79-6
Purity: 98%
Molecular Weight: 396.44
Molecular Formula: C20H24N6O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PD 166866 is a potent inhibitor for both ATP competitive pyrido [2,3-d]pyrimidine tyrosine kinase and for FGF-2 (bFGF). It has no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases, or MEK, PKC, or CDK4. PD 166866 is an inhibitor of Flg (FGFR1).


Konferenser

Zhu, X., et al.: Science, 251, 90 (1991), Davies, D.E., et al.: Biochem. Pharmacol., 51, 1101 (1996), Panek, R.L., et al.: J. Pharmacol. Exp. Ther., 286, 569 (1998), Iacoangeli, A., et al.: Biochimie, 82, 35 (2000),

Physical State :
Solid
Solubility :
Soluble in DMSO (≥10 mg/ml).
LAGRING :
Store at -20° C
Melting Point :
291-293°C (lit.)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
Fibroblast growth factor receptor 1: IC50 = 48 nM (human); c-Src : IC50 = > 50 µM; Cyclin-dependent kinase 4: IC50 = >40 µM (human); Fibroblast growth factor receptor 3: IC50 = 60 nM (human); HUVEC50 : IC50 = 100 nM (human); Fibroblast growth factor receptor 2: IC50 = 60 nM (human); C6 : IC50 = >25 µM (rat)
pK Values :
pKa: 10.15, pKb: 2.95
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
5328127
MDL Number :
MFCD12922514
SMILES :
CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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