Paroxetine maleate CAS: 64006-44-6
MF: C19H20FNO3•C4H4O4
MW: 445.44
A selective serotonin uptake inhibitor.

Paroxetine maleate (CAS 64006-44-6)

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Ansökan Paroxetine maleate is a selective serotonin uptake inhibitor
CAS Nr: 64006-44-6
Molekylvikt: 445.44
Molekylär formel: C19H20FNO3•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Paroxetine maleate displays minimal affinity for α1-, α2- or β-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM).


Konferenser

1. Thomas, D.R., et al. 1987. Psychopharmacology. 93: 193-200. PMID: 2962217
2. Owens, M.J., et al. 1997. J. Pharmacol. Exp. Ther. 283: 1305-1322. PMID: 9400006
3. Fujishiro, J., et al. 2002. Eur. J. Pharmacol. 454: 183-188. PMID: 12421645< br>

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM). Insoluble in water.
LAGRING :
Store at room temperature
Melting Point :
136-138° C
Boiling Point :
451.7° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
Optical Activity :
α20/D -70.42°, c = 0.14 in ethanol; α20/D -87°, c = 5 in ethanol
IC50 :
PhoP regulon in Salmonella typhi: IC50 = 19.17 µM
Ki Data :
Serotonin transporter: Ki= 0.05 nM; [3H]-5-HT uptake: Ki= 1.1 nM; Muscarinic ACh receptors: Ki= 42 nM; [3H]-l-NA uptake: Ki= 350 nM; [3H]-DA uptake: Ki= 1.1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TM4569300
PubChem CID :
Merck Index :
14: 7043
MDL Number :
MFCD01742665
SMILES :
C1CNC[[email protected]]([[email protected]@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C(=C/C(=O)O)\\C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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