Anti-PARD6B Antibody (B-10) is a mouse monoclonal IgG2a κ PARD6B antibody, cited in 17 publications, provided at 200 µg/ml
raised against amino acids 308-371 mapping at the C-terminus of PARD6B of mouse origin
Anti-PARD6B Antibody (B-10) is recommended for detection of PARD6B of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-PARD6B Antibody (B-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PARD6B (B-10): sc-166405.
m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PARD6B Antibody (B-10) for WB and IHC(P) applications. These reagents are now offered in bundles with PARD6B Antibody (B-10) (see ordering information below).
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PARD6B Antibody (B-10) is a high quality monoclonal PARD6B antibody (also designated PARD6 antibody) suitable for the detection of the PARD6B protein of mouse, rat and human origin. PARD6B Antibody (B-10) is available as both the non-conjugated anti-PARD6B antibody form, as well as multiple conjugated forms of anti-PARD6B antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cellular asymmetry is critical for the development of multicellular organisms. PARD (partitioning-defective) proteins play important roles in asymmetric cell division and polarized growth, whereas Cdc42 and Rac mediate establishment of cell growth and polarity and contribute to oncogenic transformation by Ras. The human PARD6, a 345 amino acid polypeptide, has a PDZ domain and a CRIB-like (Cdc42/Rac interactive binding) motif. PARD6 interacts with GTP-bound Rac and Cdc42 via this motif and with the atypical PKC isoforms PKCι/λ and PKCΩ via N-terminal head to head association. These interactions allow formation of a ternary complex in vitro and in vivo, which is implicated in the formation of normal tight junctions at epithelial cell-cell contacts and is also involved in the polarization of mother cells before asymmetric cell division in C. elegans. PARD6 acts through PARD3 by localizing or maintaining the PARD3 protein at the cell periphery. PARD6A, also designated PAR-6α, PAR6C, TAX40 and TIP-40, is expressed in pancreas, skeletal muscle, brain and heart, and is weakly expressed in kidney and placenta. PAR6B is expressed in pancreas and in both adult and fetal kidney, and is weakly expressed in placenta and lung.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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To place an order using RMB or to ship to mainland China, please visit www.scbio.cn