Anti-pan hnRNP Antibody (C-6) is a mouse monoclonal IgG1 κ pan hnRNP antibody, cited in 3 publications, provided at 200 µg/ml
raised against amino acids 61-260 mapping within an internal region of hnRNP D0 of human origin
Anti-pan hnRNP Antibody (C-6) is recommended for detection of hnRNP D0, hnRNP A/B and JKTBP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-pan hnRNP Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of pan hnRNP (C-6): sc-166577.
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) and m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) are the preferred secondary detection reagents for pan hnRNP Antibody (C-6) for WB and IHC(P) applications. These reagents are now offered in bundles with pan hnRNP Antibody (C-6) (see ordering information below).
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Labware ships FedEx Ground free of charge to the contiguous US
pan hnRNP Antibody (C-6) is a high quality monoclonal pan hnRNP antibody (also designated HNRNPD/DL/PAB antibody) suitable for the detection of the pan hnRNP protein of mouse, rat and human origin. pan hnRNP Antibody (C-6) is available as both the non-conjugated anti-pan hnRNP antibody form, as well as multiple conjugated forms of anti-pan hnRNP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to pre-mRNA processing and transport, and also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. hnRNP complexes are the major constituents of the spliceosome and in particular, the hnRNP A1 protein is one of the major pre-mRNA/mRNA binding proteins and also one of the most abundant proteins in the nucleus. hnRNP A1 and A2/B1 regulate the processing of pre-mRNA by directly antagonizing the association of various splicing factors and by influencing the splice site selection on pre-mRNA. The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. Most hnRNP proteins, including hnRNP C1 and C2, contain one or more RNA binding domains and are implicated in the processing of pre-mRNA. hnRNPs F and H are largely related factors that preferentially associate with poly(rG) regions on RNA. Isoforms of these proteins are often generated by alternative processing of the pre-mRNA and by posttranslational modifications such as phosphorylation on serines and threonines and methylation of arginines.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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