NU 7441 CAS: 503468-95-9
MF: C25H19NO3S
NU 7441 is a DNA-PK inhibitor, and antitumor agent in vitro.

NU 7441 (CAS 503468-95-9)

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Ansökan NU 7441 is a DNA-PK inhibitor, and antitumor agent in vitro
CAS Nr: 503468-95-9
Molekylvikt: 413.49
Molekylär formel: C25H19NO3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

NU7441 is a potent novel DNA-PK inhibitor. NU7441 is an antitumor agent that increases etoposide-induced tumor growth delay in vitro.


Konferenser

Caldecott, K., et al.: Cancer Res., 50, 5778 (1990), Boulton, S., et al.: Eur. J. Cancer, 36, 535 (2000), Jackson, S., et al.: Carcinogenesis, 23, 687 (2002), Sandler, A., et al.: Semin. Oncol., 30, 9 (2003), Hardcastle, I., et al.: J. Med. Chem., 48, 7829 (2005),

Physical State :
Solid
Solubility :
Soluble in methanol, ethanol (<1 mg/mL at 25° C), DMSO (3 mg/mL at 25° C), DMF (~1 mg/ml), and water (<1 mg/mL at 25° C).
LAGRING :
Store at -20° C
Melting Point :
246.28° C (Predicted)
Boiling Point :
~646.9° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.73 (Predicted)
IC50 :
DNA-PK: IC50 = 14 nM; NCI-H1770: IC50 = 21.43 nM (human); PI 3-kinase p110α: IC50 = 130 nM (human); A 172: IC50 = 153.16 nM (human); PI3K : IC50 = 5 µM
Ki Data :
DNA-PK: Ki= 0.65 (human)
pK Values :
pKb: 0.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DJ2981006
PubChem CID :
MDL Number :
MFCD11983069
SMILES :
C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56

Download SDS (MSDS)

Certificate of Analysis

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NU 7441 (CAS 503468-95-9)  Produkt Citat

See how others have used NU 7441 (CAS 503468-95-9). Click on the entry to view the PubMed entry .

Citations 1 to 9 of 9 total

PMID: # 30355591  Boel, A.|De Saffel, H.|Steyaert, W.|Callewaert, B.|De Paepe, A.|Coucke, PJ.|Willaert, A.| et al. 2018. Dis Model Mech. 11:

PMID: # 28580318  Herrero, AB. et al. 2017. Front Oncol. 7: 98.

PMID: # 28349922  Ashraf, R. et al. 2017. Sci Rep. 7: 45287.

PMID: # 26628370  Baldock, RA. et al. 2015. Cell reports. 13: 2081-9.

PMID: # 25292178  Somyajit, K. et al. 2015. Carcinogenesis. 36: 13-24.

PMID: # 26216992  Yoshida, H. et al. 2015. Proceedings of the National Academy of Sciences of the United States of America. 112: E4448-57.

PMID: # 24952786  Colis, L. et al. 2014. Oncotarget. 5: 4361-9.

PMID: # 23554979  Moore, HM. et al. 2013. PLoS ONE. 8: -.

PMID: # 24136149  Evert, M. et al. 2013. Br. J. Cancer. 109: 2654-64.

Citations 1 to 9 of 9 total
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