NPR Antibody (B-2): sc-390081
- NPR Antibody (B-2) is a mouse monoclonal IgG1 κ NPR antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 459-495 near the C-terminus of NPR of human origin
- NPR Antibody (B-2) is recommended for detection of NPR of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- Anti-NPR Antibody (B-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for NPR Antibody (B-2) for WB applications. These reagents are now offered in bundles with NPR Antibody (B-2) (see ordering information below).
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SEE ALSO...
NPR Antibody (B-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects NPR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-NPR antibody (B-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NPR protein plays a crucial role in the neuronal uptake pathway, particularly during synapse formation and remodeling, by mediating the uptake of synaptic materials, including presynaptic toxins. NPR belongs to the long pentraxin family, which is highly conserved and predominantly expressed in the brain and central nervous system, forming multimeric complexes essential for neuronal function. NPR is located on the cell membrane and can interact with neuronal pentraxin 1 and 2, forming heteropentameric complexes that are released from the membrane through proteolytic processes. NP1 gene, which is involved in this pathway, is situated on chromosome 17q25.1-q25.2, while NP2 is located on chromosome 7q21.3-122.1 and contains several potential N-linked glycosylation sites, although its specific function remains unknown. NPR′s ability to form these complexes and role in synaptic material uptake highlight its importance in maintaining synaptic integrity and facilitating communication between neurons.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NPR Antibody (B-2) References:
- Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2. | Kirkpatrick, LL., et al. 2000. J Biol Chem. 275: 17786-92. PMID: 10748068
- Inducible expression of the long pentraxin PTX3 in the central nervous system. | Polentarutti, N., et al. 2000. J Neuroimmunol. 106: 87-94. PMID: 10814786
- Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. | Hsu, YC. and Perin, MS. 1995. Genomics. 28: 220-7. PMID: 8530029
- Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization. | Omeis, IA., et al. 1996. Genomics. 36: 543-5. PMID: 8884281
- Long pentraxins: an emerging group of proteins with diverse functions. | Goodman, AR., et al. 1996. Cytokine Growth Factor Rev. 7: 191-202. PMID: 8899296
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NPR Antibody (B-2) | sc-390081 | 200 µg/ml | $316.00 | |||
NPR Antibody (B-2): m-IgG Fc BP-HRP Bundle | sc-530057 | 200 µg Ab; 10 µg BP | $354.00 | |||
NPR Antibody (B-2): m-IgGκ BP-HRP Bundle | sc-523396 | 200 µg Ab, 40 µg BP | $354.00 | |||
NPR Antibody (B-2): m-IgG1 BP-HRP Bundle | sc-543845 | 200 µg Ab; 20 µg BP | $354.00 | |||
NPR Antibody (B-2) AC | sc-390081 AC | 500 µg/ml, 25% agarose | $416.00 | |||
NPR Antibody (B-2) HRP | sc-390081 HRP | 200 µg/ml | $316.00 | |||
NPR Antibody (B-2) FITC | sc-390081 FITC | 200 µg/ml | $330.00 | |||
NPR Antibody (B-2) PE | sc-390081 PE | 200 µg/ml | $343.00 | |||
NPR Antibody (B-2) Alexa Fluor® 488 | sc-390081 AF488 | 200 µg/ml | $357.00 | |||
NPR Antibody (B-2) Alexa Fluor® 546 | sc-390081 AF546 | 200 µg/ml | $357.00 | |||
NPR Antibody (B-2) Alexa Fluor® 594 | sc-390081 AF594 | 200 µg/ml | $357.00 | |||
NPR Antibody (B-2) Alexa Fluor® 647 | sc-390081 AF647 | 200 µg/ml | $357.00 | |||
NPR Antibody (B-2) Alexa Fluor® 680 | sc-390081 AF680 | 200 µg/ml | $357.00 | |||
NPR Antibody (B-2) Alexa Fluor® 790 | sc-390081 AF790 | 200 µg/ml | $357.00 | |||
NPR (B-2) Neutralizing Peptide | sc-390081 P | 100 µg/0.5 ml | $68.00 |