Nicergoline CAS: 27848-84-6
MF: C24H26BrN3O3
MW: 484.39
An α-adrenergic modulator and vasodilator.

Nicergoline (CAS 27848-84-6)

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Alternativa namn: 5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester
Ansökan Nicergoline is an α-adrenergic modulator and vasodilator
CAS Nr: 27848-84-6
Renhet: ≥98%
Molekylvikt: 484.39
Molekylär formel: C24H26BrN3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Nicergoline is an ergot derivative and vasodilator which increases blood flow in the brain. Nicergoline inhibits the vasoconstrictor effect of catecholamines by inhibiting the postsynaptic α1-adrenoceptors on vascular smooth muscle.


Konferenser

1. Chopin, P. and Briley, M. 1992. Psychopharmacology.106: 26-30.
2. Carfagna, N., et al. 1995. Neurosci. Lett. 197: 195-198.
3. Carfagna, N., et al. 1996. Neurosci. Lett. 209: 189-192.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), alcohol, chloroform, and acetone. Insoluble in water.
LAGRING :
Store at 4° C
Melting Point :
136-138° C
Boiling Point :
~594.4° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
Optical Activity :
α20/D +5.7°±0.5°, c = 5 in EtOH (95vol%)
pK Values :
pKb: 6.33 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KE6341000
PubChem CID :
Merck Index :
14: 6496
MDL Number :
MFCD00869626
EC Number :
248-694-6
Beilstein Registry :
4828393
SMILES :
CN1C[[email protected]@H](C[[email protected]]2([[email protected]]1CC3=CN(C4=CC=CC2=C34)C)OC)COC(=O)C5=CC(=CN=C5)Br

Download SDS (MSDS)

Certificate of Analysis

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Nicergoline (CAS 27848-84-6)  Produkt Citat

See how others have used Nicergoline (CAS 27848-84-6). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24355563  Koval, AV.|Vlasov, P.|Shichkova, P.|Khunderyakova, S.|Markov, Y.|Panchenko, J.|Volodina, A.|Kondrashov, FA.|Katanaev, VL.| et al. 2014. Biochem. Pharmacol. 87: 571-8.

Citations 1 to 1 of 1 total
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