Neurokinin A (CAS 86933-74-6)

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Alternativa namn: Substance K; Neuromedin L

Ansökan Neurokinin A is an endogenous tachykinin agonist with preference for the NK-2R

CAS Nr: 86933-74-6

Molekylvikt: 1133.33

Molekylär formel: C₅₀H₈₀N₁₄O₁₄S

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Neurokinin A is a member of the endogenous tachykinin agonist with preference for the NK-2R (NK-2 receptor) with greater potency as a bronchoconstrictor than Substance P (sc-201169). The comound has shown to be identical to substance K and neuromedin L1. Neurokinin A has been reported to effect reproduction by controlling at the hypothalamus level gonadotropin and prolactin secretion along with steroid secretion at the ovarian and gonadal level. An increase in inositol 1,4,5-trisphosphate (IP3) levels along with paralleled increase in intracellular free Ca²⁺ in BHK-21 cells with the NK-2R gene were stimulated with Neurokinin A. The compound has also been observed to induce contraction in muscle strips and single cells of the human sigmoid colon circular muscle. Neurokinin A has also been used to discover the location of tachykinin receptors.

Konferenser

1. Eistetter, H.R., et al. 1993. J. Cell. Biochem. 52: 84-91. PMID: 8391539
2. Debeljuk, L. and Lasaga, M. 1999. Peptides. 20: 285-299. PMID: 10422885
3. Cao, W., et al. 2000. Gastroenterology. 119: 51-61. PMID: 10889154

Physical State :

Solid

Solubility :

Soluble in water (1 g/l) at 20° C, 10% acetonitrile / water (1 mg/ml), and 5% Acetic Acid.

LAGRING :

Store at -20° C

Boiling Point :

~1610.7° C at 760 mmHg (Predicted)

Density :

~1.3 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.58

Optical Activity :

α20/D -57.4°, c = 0.37 in 1 M AcOH

IC50 :

Neurokinin 2 receptor: IC₅₀ = 1 nM (human); Neurokinin 1 receptor: IC₅₀ = 3.5 nM (human); Neurokinin 3 receptor: IC₅₀ = 45 nM (human)

Ki Data :

Neurokinin 2 receptor: K_i= 0.71 nM (human); Neurokinin 1 receptor: K_i= 630 nM (human)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

3

PubChem CID :

55582

MDL Number :

MFCD00167560

SMILES :

CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N

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Neurokinin A (CAS 86933-74-6)

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Konferenser

Download SDS (MSDS)

Certificate of Analysis