Naltrindole Hydrochloride is the hydrochloride salt preparation of Naltrindole, which is an apoptotic agent and an inhibitor of cell growth. Naltrindole has been shown to be a cell permeable, highly potent and selective antagonist of DOR(δ opioids). Mechanistic studies show that Naltrindole treatement reduces phosphorylation of threonine 308 and Akt/PKB on serine 473 in cells. By reducing phosphorylation of Akt/PKB, downstream effectors glycogen synthase kinase-3β and transcription factors such as AFX and FKHR are also reduced.
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See how others have used Naltrindole Hydrochloride (CAS 111469-81-9). Click on the entry to view the PubMed entry .
PMID: # 23973647 Izquierdo, T. et al. 2013. Eur. J. Pharmacol. 718: 393-400.
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