Naltrindole Hydrochloride (CAS 111469-81-9)

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Ansökan Naltrindole Hydrochloride is a δ opioid (DOR) receptor antagonist

CAS Nr: 111469-81-9

Renhet: ≥95%

Molekylvikt: 451.0

Molekylär formel: C₂₆H₂₆N₂O₃•HCl

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Naltrindole Hydrochloride is the hydrochloride salt preparation of Naltrindole, which is an apoptotic agent and an inhibitor of cell growth. Naltrindole has been shown to be a cell permeable, highly potent and selective antagonist of DOR(δ opioids). Mechanistic studies show that Naltrindole treatement reduces phosphorylation of threonine 308 and Akt/PKB on serine 473 in cells. By reducing phosphorylation of Akt/PKB, downstream effectors glycogen synthase kinase-3β and transcription factors such as AFX and FKHR are also reduced.

Konferenser

1. Portoghese, P.S., et al. 1991. J. Med. Chem. 34: 1715-1720. PMID: 1851846
2. Verborgh, C., et al. 1999. Pharmacol. Biochem. Behav. 63: 175-183. PMID: 10340539
3. Chen, Y.L., et al. 2004. Cancer Res. 64: 8723-8730. PMID: 15574783

Physical State :

Solid

Solubility :

Soluble in water (8 mg/ml), and methanol (4.5 mg/ml).

LAGRING :

Store at -20° C

Refractive Index :

n²⁰_D 1.80 (Predicted)

IC50 :

Growth of NCI-H69: IC₅₀ = 25 µM; Growth of NCI-H345: IC₅₀ = 40 µM; Growth of NCI-H510 : IC₅₀ = 55 µM

Ki Data :

MOR-1: K_i= 3.8 nM; KOR-1: K_i= 332.7 nM; DOR-1: K_i= 31 pM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

PB9092200

PubChem CID :

16760573

MDL Number :

MFCD00069313

SMILES :

C1CC1CN2CC[[email protected]]34[[email protected]@H]5C6=C(C[[email protected]]3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8N6.Cl

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Certificate of Analysis

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Naltrindole Hydrochloride (CAS 111469-81-9) Produkt Citat

See how others have used Naltrindole Hydrochloride (CAS 111469-81-9). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23973647 Izquierdo, T. et al. 2013. Eur. J. Pharmacol. 718: 393-400.

Citations 1 to 1 of 1 total

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