Naltrindole Hydrochloride CAS: 111469-81-9
MF: C26H26N2O3•HCl
MW: 451.0
A δ opioid (DOR) receptor antagonist.

Naltrindole Hydrochloride (CAS 111469-81-9)

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Naltrindole Hydrochloride is rated 5.0 out of 5 by 1.
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Ansökan Naltrindole Hydrochloride is a δ opioid (DOR) receptor antagonist
CAS Nr: 111469-81-9
Renhet: ≥95%
Molekylvikt: 451.0
Molekylär formel: C26H26N2O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Naltrindole Hydrochloride is the hydrochloride salt preparation of Naltrindole, which is an apoptotic agent and an inhibitor of cell growth. Naltrindole has been shown to be a cell permeable, highly potent and selective antagonist of DOR(δ opioids). Mechanistic studies show that Naltrindole treatement reduces phosphorylation of threonine 308 and Akt/PKB on serine 473 in cells. By reducing phosphorylation of Akt/PKB, downstream effectors glycogen synthase kinase-3β and transcription factors such as AFX and FKHR are also reduced.


Konferenser

1. Portoghese, P.S., et al. 1991. J. Med. Chem. 34: 1715-1720. PMID: 1851846
2. Verborgh, C., et al. 1999. Pharmacol. Biochem. Behav. 63: 175-183. PMID: 10340539
3. Chen, Y.L., et al. 2004. Cancer Res. 64: 8723-8730. PMID: 15574783

Physical State :
Solid
Solubility :
Soluble in water (8 mg/ml), and methanol (4.5 mg/ml).
LAGRING :
Store at -20° C
Refractive Index :
n20D 1.80 (Predicted)
IC50 :
Growth of NCI-H69: IC50 = 25 µM; Growth of NCI-H345: IC50 = 40 µM; Growth of NCI-H510 : IC50 = 55 µM
Ki Data :
MOR-1: Ki= 3.8 nM; KOR-1: Ki= 332.7 nM; DOR-1: Ki= 31 pM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
PB9092200
PubChem CID :
MDL Number :
MFCD00069313
SMILES :
C1CC1CN2CC[[email protected]]34[[email protected]@H]5C6=C(C[[email protected]]3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8N6.Cl

Download SDS (MSDS)

Certificate of Analysis

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Naltrindole Hydrochloride (CAS 111469-81-9)  Produkt Citat

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Citations 1 to 1 of 1 total

PMID: # 23973647  Izquierdo, T. et al. 2013. Eur. J. Pharmacol. 718: 393-400.

Citations 1 to 1 of 1 total
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