Naltriben methanesulfonate (CAS 111555-58-9)

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Alternativa namn: NTB

Ansökan Naltriben methanesulfonate is a highly selective δ2 opioid receptor (DOR) antagonist

CAS Nr: 111555-58-9

Molekylvikt: 511.59

Molekylär formel: C₂₆H₂₅NO₄•CH₄O₃S

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

Naltriben methanesulfonate: sc-301456...

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Naltriben methanesulfonate is a highly selective DOR (δ2 opioid receptor ) antagonist. Ligand binding assays show biphasic binding of the antagonist to the single receptor type.

Konferenser

Szekeres, P.G., Traynor, J.R., Delta opioid modulation of the binding of guanosine-5′-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects. J. Pharmacol. Exp. Ther. 283, 1276, (1997) Abstract Takemori, A.E., et al., Agonist and antagonist activities of ligands derived from naltrexone and oxymorphone. Life Sci. 50, 1491-1495, (1992) Abstract Miyamoto, Y., et al., Involvement of δ2 opioid receptors in the development of morphine dependence in mice. J. Pharmacol. Exp. Ther. 264, 1141-1145, (1993) Abstract

Physical State :

Solid

Solubility :

Soluble in DMSO (14 mg/ml at ~60° C).

LAGRING :

Store at -20° C

Melting Point :

277-278° C

Refractive Index :

n²⁰_D ~1.78 (Predicted)

Ki Data :

δ-opioid receptor: K_i= 0.01 nM; μ-opioid receptor: K_i= 19 nM; κ-opioid receptor: K_i= 152 nM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

3

RTECS :

PB9175000

PubChem CID :

11957658

MDL Number :

MFCD11046015

SMILES :

CS(=O)(=O)O.C1CC1CN2CCC34[[email protected]@H]5C6=C(C[[email protected]]3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8O6

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Certificate of Analysis

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