Naloxone hydrochloride CAS: 357-08-4
MF: C19H21NO4•HCl
MW: 363.84
A nonspecific opiate receptor antagonist that displays anitnociceptive effects.

Naloxone hydrochloride (CAS 357-08-4)

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Naloxone hydrochloride is rated 5.0 out of 5 by 1.
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Alternativa namn: (5α)-17-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
Ansökan Naloxone hydrochloride is a nonspecific opiate receptor antagonist that displays anitnociceptive effects
CAS Nr: 357-08-4
Molekylvikt: 363.84
Molekylär formel: C19H21NO4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).

Naloxone hydrochloride is a nonspecific opiate receptor antagonist that displays anitnociceptive effects. Studies have identified this product as a significant immunoadjuvant in cancer immunotherapy. Reportedly exhibits the ability to reverse various types of cardiovas Naloxone hydrochloride is an inhibitor of DOR, KOR, MOR and Sigma Receptor.


Konferenser

1. McNicholas, L.F., et al. 1984. Drugs. 27: 81-93. PMID: 6319107
2. Joshi, G.G., et al. 2009. Indian J Gastroenterol. 28: 180-182. PMID: 20107967
3. Molla Hassan, A.T., et al. 2009. Int. Immunopharmacol. 9: 1381-1386. PMID: 19706340
4. Tallett, A.J., et al. 2009. Pharmacol. Biochem. Behav. 91: 358-366. PMID: 18755211

Physical State :
Solid
Solubility :
Soluble in water (73 mg/ml), ethanol (3.3 mg/ml), methanol (50 mg/ml), and DMSO (73 mg/ml). Insoluble in ether.
LAGRING :
Store at 4° C
Melting Point :
182° C
Refractive Index :
n20D 1.69 (Predicted)
Optical Activity :
α20/D -160°, c = 0.5 in water
IC50 :
Adenosine A3-R: IC50 = 1.6 nM (human); MOR-1: IC50 = 2 nM (human); Mu opioid receptor : IC50 = 5 nM (bovine); Opioid receptors; mu/kappa/delta: IC50 = 43 nM (human); DOR-1: IC50 = 138 nM (human)
Ki Data :
Mu opioid receptor : Ki= 0.23 nM (rat); KOR-1: Ki= 0.25 nM (human); Mu opioid receptor : Ki= 0.68 nM (guinea pig); Mu opioid receptor : Ki= 1.07 nM (rat); Kappa opioid receptor: Ki= 3.17 nM (guinea pig)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
WGK Germany :
3
RTECS :
QD2275000
PubChem CID :
Merck Index :
14: 6362
MDL Number :
MFCD00069322
EC Number :
206-611-0
Beilstein Registry :
6260807
SMILES :
C=CCN1CCC23C4C(=O)CCC2(C1CC5=C3C(=C(C=C5)O)O4)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Naloxone hydrochloride (CAS 357-08-4)  Produkt Citat

See how others have used Naloxone hydrochloride (CAS 357-08-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30582909  Eur J Pharmacol. 32-39.

Citations 1 to 1 of 1 total
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