Nalmefene hydrochloride (CAS 58895-64-0)

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Ansökan Nalmefene hydrochloride is an opioid receptor antagonist

CAS Nr: 58895-64-0

Molekylvikt: 375.89

Molekylär formel: C₂₁H₂₅NO₃•HCl

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

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Nalmefene hydrochloride has been reported to be an opioid receptor antagonist. The opioid family of G-protein-coupled receptors contains three types of opioids; μ opioid receptor (MOR), δ opioid receptor (DOR), and κ opioid receptor (KOR).

Physical State :

Solid

Solubility :

Soluble in water (>25 mg/ml), DMSO (100 mM), and chloroform (0.13 mg/ml).

LAGRING :

Desiccate at room temperature

Boiling Point :

507.9° C at 760 mmHg (Predicted)

IC50 :

Kappa opioid receptor: IC₅₀ <500 nM (human); Beta-galactosidase: EC₅₀50 >31500 nM (Escherichia coli)

Ki Data :

Kappa opioid receptor: K_i= 0.12 nM (human); Mu opioid receptor: K_i= 0.29 nM (Rattus norvegicus); Mu opioid receptor: K_i= 0.44 nM (human); Kappa opioid receptor: K_i= 1.03 nM (human); Delta opioid receptor: K_i= 3.4 nM (Rattus norvegicus)

pK Values :

pK_a: 9.38 (Predicted), 7.6, pK_b: 7.68 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

RTECS :

QC7699000

PubChem CID :

5388881

Merck Index :

14: 6360

MDL Number :

MFCD07772293

SMILES :

C=C1CC[[email protected]]2([[email protected]]3CC4=C5[[email protected]]2([[email protected]]1OC5=C(C=C4)O)CCN3CC6CC6)O.Cl

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Certificate of Analysis

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