N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) CAS: 139332-94-8
MF: C25H41NO3S
MW: 435.7
A methyltransferase substrate.

N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) (CAS 139332-94-8)

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Ansökan A methyltransferase substrate
Momsregistreringsnummer :: 139332-94-8
Purity: ≥98%
Molecular Weight: 435.7
Molecular Formula: C25H41NO3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC) is a substrate for the carboxyl methyltransferase that is shown to inhibit Ras carboxyl methylation. The Ras subfamily is usually responsible for cell proliferation and inhibition of it will cause a halt in cell division. This compound has been noted to also be a competitive inhibitor for prenylcysteine methyl transferase which doubles the rate of basal and stimulates insulin secretion in a reversible and ATP-dependent manner. Additionally, this agent has been found to inhibit Integrin β2-induced actin polymerization in neutrophils.


1. Volker, C., et al. 1991. FEBS Lett. 295: 189-194. PMID: 1765152
2. Philips, M.R., et al. 1993. Science. 259: 977-980. PMID: 8438158
3. Regazzi, R., et al. 1995. Biochim. Biophys. Acta. 1268: 269-278. PMID: 7548225

Appearance :
Viscous oil
Physical State :
Solubility :
Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml), ethyl acetate, water (11 mg/ml) at 25° C, 0.1M Na2CO3 (11 mg/ml), and DMF (~33 mg/ml).
Store at -20° C
Refractive Index :
n20D 1.52
IC50 :
Signal transduction that are receptor mediated: IC50 = 4 µM (human neutrophils); b2-integrin-induced actin polymerization: IC50 = ~45 nM (neutrophils)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :
EC Number :

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Certificate of Analysis

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N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC)  Produkt Citat

See how others have used N-Acetyl-S-geranylgeranyl-L-cysteine (AGGC). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27710830  Zhao, Y. et al. 2016. Eur. J. Cancer. 68: 38-50.

Citations 1 to 1 of 1 total
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