Mithramycin A CAS: 18378-89-7
MF: C52H76O24
MW: 1085.15
A polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA.

Mithramycin A (CAS 18378-89-7)

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Synonym: Aureolic acid;Plicamycin
Ansökan A polymerase inhibitor that binds to GC rich sequences located in the minor groove of DNA
Momsregistreringsnummer :: 18378-89-7
Purity: >96%
Molecular Weight: 1085.15
Molecular Formula: C52H76O24
* Refer to Certificate of Analysis for lot specific data (including water content).
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Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-α and Fas-ligand induced apoptosis. As a DNA binding transcriptional inhibitor, mithramycin A binds to GC rich sequences located in the minor groove of DNA and is noted to be reversible and Mg2+ dependent. Additionally reported to a block transcriptional activation of the SV40 promoter via competitive binding against Sp1 transcription factor to GC rich areas in the early promoter. Mithramycin A is noted to supress TNF-α induced expression of fractalkine (CX3CL1) mRNA in a dose-dependent manner and to act as an effective differentiation agent of HL60 promyelocytic leukemia cells.


Konferenser

1. Ray, R., et al. 1989. J. Clin. Invest. 83: 2003-2007. PMID: 2542379
2. Mir, M.A., et al. 2003. Bioorg. Med. Chem. 11: 2791-2801. PMID: 12788353
3. Ahn, S.Y., et al. 2004. Am. J. Pathol. 164: 1663-1672. PMID: 15111313
4. Leroy, I., et al. 2006. Apoptosis. 11: 113-119. PMID: 16374547
5. Mansilla, S., et al. 2010. Biochem. Pharmacol. 79: 1418-1427. PMID: 20093108

Usage :
Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Derived From :
Streptomyces argillaceus
Solubility :
Soluble in phosphate buffered saline (1 mg/ml), ethanol, ethyl acetate, lower alcohols, and acetone. Insoluble in water.
LAGRING :
Store at -20° C
Melting Point :
164-170° C
Boiling Point :
1169.8° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.64
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
PZ2800000
PubChem CID :
230076
Merck Index :
14: 7536
MDL Number :
MFCD00135618
Beilstein Registry :
5236667
SMILES :
CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O

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Certificate of Analysis

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Mithramycin A  Produkt Citat

See how others have used Mithramycin A. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 29778644  Hepp, MI. et al. 2018. Biochim. Biophys. Acta.

PMID: # 29344898  2018. Methods Mol. Biol. 1711: 351-398.

PMID: # 26908121  Bai, D. et al. 2016. Scientific reports. 6: 22068.

PMID: # 26317415  Okoro, EU. et al. 2015. PLoS ONE. 10: e0136895.

Citations 1 to 4 of 4 total
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