Melittin CAS: 37231-28-0
MF: C131H229N39O31
MW: 2846.45
An apoptosis inducer, NF-κB inhibitor, and PLA2 activator.

Melittin (CAS 37231-28-0)

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Synonym: GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
Ansökan An apoptosis inducer, NF-κB inhibitor, and PLA2 activator
Momsregistreringsnummer :: 37231-28-0
Purity: ≥97%
Molecular Weight: 2846.45
Molecular Formula: C131H229N39O31
* Refer to Certificate of Analysis for lot specific data (including water content).
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Melittin, an antibacterial originally derived from Apis mellifera, has been reported to cause apoptosis via induction of reactive oxygen species production in cells. Additionally, this compound has been found to suppress 4α-Phorbol 12-myristate 13-acetate (sc-202021) induced invasion of proliferative cells via inhibition of activator protein-1 and NF-κB. Other experiments show Melittin to be able to also suppress PMA-induced phosphorylation of ERK and JNK mitogen-activated protein kinases. This compound also activates phospholipase A2 (PLA2).


Konferenser

1. Han, S., et al. 2009. J Asian Nat Prod Res. 11: 796-804. PMID: 20183327
2. Park, C., et al. 2010. Biochem. Biophys. Res. Commun. 394: 170-172. PMID: 20188067
3. Park, J.H., et al. 2010. Mol. Cells. 29: 209-215. PMID: 20082219

Appearance :
Powder
Physical State :
Solid
Derived From :
Synthetic
Sequence :
Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
Solubility :
Soluble in water, and 20% acetonitrile (1 mg/ml).
LAGRING :
Store at -20° C
Ki Data :
Protein kinase C: Ki= 5-7 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
OS3960000
PubChem CID :
16133648
Merck Index :
14: 5824
MDL Number :
MFCD00076868
EC Number :
253-417-7
SMILES :
CC[[email protected]](C)[[email protected]@H](C(=O)NCC(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](C(C)C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H]([[email protected]@H](C)O)C(=O)N[[email protected]@H]([[email protected]@H](C)O)C(=O)NCC(=O)N[[email protected]@H](CC(C)C)C(=O)N1CCC[[email protected]]1C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)N[[email protected]@H](CO)C(=O)N[[email protected]@H](CC2=CNC3=CC=CC=C32)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](CCCNC(=N)N)C(=O)N[[email protected]@H](CCCCN)C(=O)N[[email protected]@H](CCCNC(=N)N)C(=O)N[[email protected]@H](CCC(=O)N)C(=O)N[[email protected]@H](CCC(=O)N)C(=O)N)NC(=O)CN

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Certificate of Analysis

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Melittin  Produkt Citat

See how others have used Melittin. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25755832  Wang, X. et al. 2015. Am J Transl Res. 7: 100-10.

PMID: # 31057657  Evid Based Complement Alternat Med. 2019: 9602935.

Citations 1 to 2 of 2 total
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