Anti-megalin/LRP2 Antibody (G-9) is a mouse monoclonal IgG1 κ megalin/LRP2 antibody, cited in 8 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 4581-4604 within a C-terminal cytoplasmic domain of megalin of rat origin
Anti-megalin/LRP2 Antibody (G-9) is recommended for detection of megalin of mouse and rat origin by WB, IP, IF, IHC(P) and ELISA
Anti-megalin/LRP2 Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of megalin/LRP2 (G-9): sc-515750.
m-IgG1 BP-HRP is the preferred secondary detection reagent for megalin/LRP2 Antibody (G-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with megalin/LRP2 Antibody (G-9) (see ordering information below).
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
megalin Antibody (G-9) is a high quality monoclonal megalin antibody (also designated Lrp2 antibody) suitable for the detection of the megalin protein of mouse and rat origin. megalin Antibody (G-9) is available as both the non-conjugated anti-megalin antibody form, as well as multiple conjugated forms of anti-megalin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Members of the LDL receptor gene family, including LDLR (low density lipo-protein receptor), LRP (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and ApoER2, are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Megalin is expressed on the apical membrane domain of epithelial cells, including proximal kidney tubules, intestine and ependymal cells. Proper folding and trafficking of megalin is facilitated by the receptor-associated protein (RAP), a molecular chaperone that can block the uptake of all known ligands for megalin. Specifically, megalin mediates the uptake of apolipoprotein J (apoJ, also designated Clusterin), which is a binding protein for the b-Amyloid peptide, a peptide implicated in Alzheimer′s disease. Megalin is also an antigenic determinant for Heymann nephritis in rats and may be important in the reabsorption of several molecules, including vitamin B12, in the kidney.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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To place an order using RMB or to ship to mainland China, please visit www.scbio.cn