MCI-186 CAS: 89-25-8
MF: C10H10N2O
MW: 174.20
A free radical scavenger that enhances NGF protein levels via the JNK pathway.

MCI-186 (CAS 89-25-8)

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Synonym: 3-Methyl-1-phenyl-2-pyrazolin-5-one; Edaravone; NSC 2629
Ansökan A free radical scavenger that enhances NGF protein levels via the JNK pathway
Momsregistreringsnummer :: 89-25-8
Purity: ≥98%
Molecular Weight: 174.20
Molecular Formula: C10H10N2O
* Refer to Certificate of Analysis for lot specific data (including water content).
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MCI-186, also known as 3-methyl-1-phenyl-2-pyrazolin-5-one, is a free radical scavenger that has been shown to contain protective properties towards murine brain ischemia. In vitro this compound has been reported to decrease cell death in murine models. Mechanistic studies suggest that MCI-186 enhances neuronal growth factor (NGF) protein levels which are essential for neuronal growth and survival. Furthermore, the enhancement of NGF expression in astrocytes has been thought to be done via the c-Jun N-terminal Kinase (JNK) pathway.


Konferenser

1. Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281: 921-927. PMID: 9152402
2. Zhou, F., et al. 2009. Brain Inj. 23: 353-357. PMID: 19330597
3. Lee, B.J., et al. 2010. Brain Res. 1307: 22-27. PMID: 19840779
4. Yoshida, H., et al. 2010. Neurosci. Res. 66: 284-289. PMID: 19954754

Physical State :
Solid
Solubility :
Soluble in water (3.3 g/L) at 20° C, DMSO (~30 mg/ml), methanol, ethanol (~15 mg/ml), DMF (~50 mg/ml), and a 1:9 solution of DMF:PBS(pH7.2) (~0.1 mg/ml).
LAGRING :
Store at room temperature
Melting Point :
126-128° C (lit.)
Boiling Point :
287° C at 265 mmHg
Density :
1.12 g/cm3 at 20° C
Refractive Index :
n20D 1.61
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
UQ9625000
PubChem CID :
4021
Merck Index :
14: 6713
MDL Number :
MFCD00003138
EC Number :
201-891-0
Beilstein Registry :
609575
SMILES :
CC1=NN(C(=O)C1)C2=CC=CC=C2

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Certificate of Analysis

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MCI-186  Produkt Citat

See how others have used MCI-186. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 26886752  Jangra, A. et al. 2016. Cell. Mol. Neurobiol.

PMID: # 19570630  Sano, H. et al. 2010. Auris Nasus Larynx. 37: 42-46.

PMID: # 19590930  Itoh, T. et al. 2009. Neurotox Res. 16: 378-389.

PMID: # 19666924  Maeno, T. et al. 2009. Br J Ophthalmol. 93: 1479-1482.

PMID: # 19645061  Iida, H. et al. 2009. Muscle Nerve. 40: 582-588.

PMID: # 14666020  Takahashi, G. et al. 2003. J. Thorac. Cardiovasc. Surg. 126: 1461-1466.

Citations 1 to 6 of 6 total
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