Anti-MCCA Antibody (B-7) is a mouse monoclonal IgG2a κ MCCA antibody, cited in 1 publications, provided at 200 µg/ml
raised against amino acids 436-725 mapping at the C-terminus of MCCA of human origin
Anti-MCCA Antibody (B-7) is recommended for detection of MCCA of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-MCCA Antibody (B-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of MCCA (B-7): sc-365754.
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) and m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) are the preferred secondary detection reagents for MCCA Antibody (B-7) for WB applications. These reagents are now offered in bundles with MCCA Antibody (B-7) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
MCCA Antibody (B-7) is a high quality monoclonal MCCA antibody (also designated MCCA antibody) suitable for the detection of the MCCA protein of mouse, rat and human origin. MCCA Antibody (B-7) is available as both the non-conjugated anti-MCCA antibody form, as well as multiple conjugated forms of anti-MCCA antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. 3-methylcrotonyl-CoA:carboxylase (MCC) is an enzyme crucial in the breakdown of the branched chain amino acid leucine. Methylcrotonoyl-CoA carboxylase α chain (MCCA), also designated 3-methylcrotonyl-CoA carboxylase 1, is located in the mitochondrial matrix. MCCA functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. MCCA has a Biotin cofactor. The gene encoding for the 725 amino acid MCCA protein maps to chromosome 3q26-q28 and consists of 19 exons. Defects in this gene are associated with 3-methylcrotonylglycinuria (MCGI), an autosomal recessive disorder characterized by muscular hypotonia and atrophy. Human MCC deficiency, also inherited recessively, is characterized by 3-methylcrotonyl-CoA accumulation. Symptoms may be highly variable, ranging from completely asymptomatic to metabolic acidosis and death in infancy.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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